基因组学和遗传研究中的知情同意。
Informed consent in genomics and genetic research.
机构信息
Center for Medical Ethics and Health Policy, Baylor College of Medicine, Houston, TX 77030, USA.
出版信息
Annu Rev Genomics Hum Genet. 2010;11:361-81. doi: 10.1146/annurev-genom-082509-141711.
Abstract
There are several features of genetic and genomic research that challenge established norms of informed consent. In this paper, we discuss these challenges, explore specific elements of informed consent for genetic and genomic research conducted in the United States, and consider alternative consent models that have been proposed. All of these models attempt to balance the obligation to respect and protect research participants with the larger social interest in advancing beneficial research as quickly as possible.
摘要
遗传和基因组研究有几个特点，对既定的知情同意规范提出了挑战。本文讨论了这些挑战，探讨了在美国进行的遗传和基因组研究中知情同意的具体要素，并考虑了已经提出的替代同意模式。所有这些模式都试图在尊重和保护研究参与者的义务与尽快推进有益研究的更大社会利益之间取得平衡。
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