Tufts University, Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, 711 Washington Street, Boston, MA 02111, USA.
Expert Rev Clin Immunol. 2006 Jul;2(4):561-7. doi: 10.1586/1744666X.2.4.561.
Vitamin E is a chain-breaking antioxidant that protects membranes from free-radical damage. Evidence suggests significant impact of vitamin E on the modulation of immune functions. Results from animal and human studies indicate that vitamin E deficiency impairs both humoral and cell-mediated immune functions. Supplementation of vitamin E above the recommended levels has been shown to enhance immune functions and to be associated with increased resistance against several pathogens, especially in the aged. The current vitamin E consumption status from diets, the status of vitamin E supplement use, the effects of vitamin E on different aspects of immune functions and mechanisms of its action and the clinical significance of vitamin E supplementation will be reviewed.
维生素 E 是一种链断裂抗氧化剂，可保护细胞膜免受自由基损伤。有证据表明，维生素 E 对免疫功能的调节有显著影响。动物和人体研究的结果表明，维生素 E 缺乏会损害体液和细胞介导的免疫功能。补充推荐水平以上的维生素 E 已被证明可以增强免疫功能，并与增加对几种病原体的抵抗力有关，尤其是在老年人中。将对饮食中的维生素 E 摄入现状、维生素 E 补充剂的使用情况、维生素 E 对免疫功能不同方面的影响及其作用机制以及维生素 E 补充的临床意义进行综述。
