Adler L E, Waldo M C
Dept. of Psychiatry, University of Colorado Health Sciences Center, Denver 80262.
Schizophr Bull. 1991;17(1):19-24. doi: 10.1093/schbul/17.1.19.
We propose a model for schizophrenia that incorporates findings of impaired auditory sensory gating with a possible structural abnormality of the hippocampus. The deficit in auditory sensory gating would be a genetic schizotaxic factor, necessary in the development of schizophrenia but not sufficient by itself. Genetic or acquired hippocampal dysgenesis or frank damage in combination with the sensory gating deficit would be necessary to produce the full-blown syndrome. We review the relevant literature and reply to Dr. E. Fuller Torrey's hypothesis.
我们提出了一种精神分裂症模型，该模型整合了听觉感觉门控受损的研究结果以及海马体可能存在的结构异常。听觉感觉门控缺陷将是一种遗传性精神分裂症相关因素，它在精神分裂症的发展过程中是必要的，但仅凭自身并不充分。遗传性或后天性海马发育异常或明显损伤，再加上感觉门控缺陷，对于产生全面发作的综合征来说将是必要的。我们回顾了相关文献并回应了E. 富勒·托里博士的假说。
