Bousman Chad A, Glatt Stephen J, Cherner Mariana, Atkinson J Hampton, Grant Igor, Tsuang Ming T, Everall Ian P
Department of Psychiatry, University of California San Diego, La Jolla, CA 92103, USA.
Psychiatry Res. 2010 Jul 30;178(2):295-8. doi: 10.1016/j.psychres.2009.07.019. Epub 2010 May 15.
Research into the biological processes that increase susceptibility to methamphetamine dependence has been conducted primarily in Asian populations. Using a case-control design this study's purpose was to explore, among a population of methamphetamine-dependent Caucasians, six putative single nucleotide polymorphisms previously found to be associated with methamphetamine dependence in Asian populations. A total of 193 non-psychotic males (117 methamphetamine-dependent and 76 controls) were genotyped for variants located in six genes (AKT1, ARRB2, BDNF, COMT, GSTP1, OPRM1). Genotypic and allelic frequencies, odds ratios, and 95% confidence intervals were calculated. None of the putative gene associations was significantly replicated in our sample of Caucasian men. Effect size comparisons suggest a trend toward allelic divergence for arrestin beta 2 (ARRB2) and glutathione S-transferase P1 (GSTP1) and allelic convergence for brain-derived neurotrophic factor (BDNF). Results provide preliminary support for further exploration and validation of candidate single nucleotide polymorphisms (SNPs) for methamphetamine (METH) dependence reported among Asian populations across other ethnic/ancestral groups.
关于增加甲基苯丙胺成瘾易感性的生物学过程的研究主要在亚洲人群中进行。本研究采用病例对照设计，目的是在甲基苯丙胺成瘾的高加索人群中，探究先前在亚洲人群中发现的六种假定的单核苷酸多态性，这些多态性与甲基苯丙胺成瘾有关。对总共193名非精神病男性（117名甲基苯丙胺成瘾者和76名对照者）进行基因分型，检测位于六个基因（AKT1、ARRB2、BDNF、COMT、GSTP1、OPRM1）中的变体。计算了基因型和等位基因频率、比值比以及95%置信区间。在我们的高加索男性样本中，没有一个假定的基因关联得到显著重复。效应大小比较表明，β-arrestin 2（ARRB2）和谷胱甘肽S-转移酶P1（GSTP1）存在等位基因差异趋势，而脑源性神经营养因子（BDNF）存在等位基因趋同趋势。研究结果为进一步探索和验证亚洲人群中报道的甲基苯丙胺（METH）成瘾候选单核苷酸多态性（SNP）在其他种族/祖先群体中的情况提供了初步支持。
