• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Mechanism of the reaction catalyzed by the DNA untwisting enzyme: attachment of the enzyme to 3'-terminus of the nicked DNA.

作者信息

Champoux J J

出版信息

J Mol Biol. 1978 Jan 25;118(3):441-6. doi: 10.1016/0022-2836(78)90238-3.

DOI:10.1016/0022-2836(78)90238-3
PMID:204790
Abstract
摘要

相似文献

1
Mechanism of the reaction catalyzed by the DNA untwisting enzyme: attachment of the enzyme to 3'-terminus of the nicked DNA.
J Mol Biol. 1978 Jan 25;118(3):441-6. doi: 10.1016/0022-2836(78)90238-3.
2
The role of single-strand breaks in the catenation reaction catalyzed by the rat type I topoisomerase.单链断裂在大鼠I型拓扑异构酶催化的连环反应中的作用。
J Biol Chem. 1986 Apr 15;261(11):5130-7.
3
Strand breakage by the DNA untwisting enzyme results in covalent attachment of the enzyme to DNA.DNA解旋酶造成的链断裂导致该酶与DNA共价连接。
Proc Natl Acad Sci U S A. 1977 Sep;74(9):3800-4. doi: 10.1073/pnas.74.9.3800.
4
Interaction of the DNA untwisting enzyme with the SV40 nucleoprotein complex.DNA解旋酶与SV40核蛋白复合体的相互作用。
Nucleic Acids Res. 1978 Feb;5(2):623-35. doi: 10.1093/nar/5.2.623.
5
Renaturation of complementary single-stranded DNA circles: complete rewinding facilitated by the DNA untwisting enzyme.互补单链DNA环的复性：DNA解旋酶促进完全重绕
Proc Natl Acad Sci U S A. 1977 Dec;74(12):5328-32. doi: 10.1073/pnas.74.12.5328.
6
Phosphorylation of double-stranded DNAs by T4 polynucleotide kinase.T4多核苷酸激酶对双链DNA的磷酸化作用。
Biochemistry. 1976 May 4;15(9):1858-65. doi: 10.1021/bi00654a011.
7
Studies on the regulation and specificity of the DNA-untwisting enzyme.
Cold Spring Harb Symp Quant Biol. 1979;43 Pt 1:53-8. doi: 10.1101/sqb.1979.043.01.009.
8
Enzymic in vitro repair and chemical nature of DNA chain breaks induced by incorporated phosphorus-32P decay.掺入的磷-32P衰变诱导的DNA链断裂的体外酶促修复及化学性质
Nucleic Acids Res. 1975 May;2(5):635-46. doi: 10.1093/nar/2.5.635.
9
Polynucleotide kinase: functional purification and use in the direct kinetic measurement of single- and double- strand cleavages of DNA by restriction and other endonucleases of limited action.多核苷酸激酶：功能纯化及其在通过限制性内切酶和其他作用有限的内切核酸酶对DNA单链和双链切割的直接动力学测量中的应用。
Anal Biochem. 1977 May 1;79(1-2):63-72. doi: 10.1016/0003-2697(77)90379-7.
10
Breakage of single-stranded DNA by rat liver nicking-closing enzyme with the formation of a DNA-enzyme complex.大鼠肝脏切口-封闭酶对单链DNA的断裂及DNA-酶复合物的形成
Nucleic Acids Res. 1980 Dec 20;8(24):6129-42. doi: 10.1093/nar/8.24.6129.

引用本文的文献

1
Common Chemical Inductors of Replication Stress:  Focus on Cell-Based Studies.复制应激的常见化学诱导剂：聚焦于细胞研究
Biomolecules. 2017 Feb 21;7(1):19. doi: 10.3390/biom7010019.
2
Pharmacokinetic modeling of absorption behavior of 9-aminocamptothecin (9-AC) released from colon-specific HPMA copolymer-9-AC conjugate in rats.大鼠体内结肠靶向性聚（N-（2-羟丙基）甲基丙烯酰胺）共聚物-9-氨基喜树碱缀合物释放的9-氨基喜树碱（9-AC）吸收行为的药代动力学建模
Pharm Res. 2008 Jan;25(1):218-26. doi: 10.1007/s11095-007-9465-3. Epub 2007 Oct 11.
3
Biodistribution and pharmacokinetics of colon-specific HPMA copolymer--9-aminocamptothecin conjugate in mice.
结肠靶向性聚（N-（2-羟丙基）甲基丙烯酰胺）共聚物-9-氨基喜树碱偶联物在小鼠体内的生物分布和药代动力学
J Control Release. 2007 Feb 12;117(2):179-85. doi: 10.1016/j.jconrel.2006.10.024. Epub 2006 Oct 27.
4
Topoisomerase I amino acid substitutions, Gly185Arg and Asp325Glu, confer camptothecin resistance in Leishmania donovani.拓扑异构酶I的氨基酸取代，即甘氨酸185突变为精氨酸和天冬氨酸325突变为谷氨酸，赋予杜氏利什曼原虫对喜树碱的抗性。
Antimicrob Agents Chemother. 2005 Apr;49(4):1441-6. doi: 10.1128/AAC.49.4.1441-1446.2005.
5
Camptothecins: a review of their chemotherapeutic potential.喜树碱类：对其化疗潜力的综述
Drugs. 2002;62(14):2039-57. doi: 10.2165/00003495-200262140-00004.
6
Phase II study of topotecan in metastatic hormone-refractory prostate cancer.
Invest New Drugs. 1995;13(3):235-40. doi: 10.1007/BF00873806.
7
Modulation of antitumor alkylating agents by novobiocin, topotecan, and lonidamine.新生霉素、拓扑替康和氯尼达明对抗肿瘤烷化剂的调节作用。
Cancer Chemother Pharmacol. 1993;32(6):455-62. doi: 10.1007/BF00685890.
8
Preferential binding of human topoisomerase I to superhelical DNA.人拓扑异构酶I与超螺旋DNA的优先结合。
EMBO J. 1995 Nov 1;14(21):5399-409. doi: 10.1002/j.1460-2075.1995.tb00224.x.
9
Ethidium bromide-mediated renaturation of denatured closed circular DNAs. The nature of denaturation-resistant fractions of bacteriophage PM2 closed circular DNA.溴化乙锭介导的变性闭环DNA复性。噬菌体PM2闭环DNA抗变性组分的性质。
Nucleic Acids Res. 1980 Feb 11;8(3):673-701. doi: 10.1093/nar/8.3.673.
10
Nucleotide sequence preference at rat liver and wheat germ type 1 DNA topoisomerase breakage sites in duplex SV40 DNA.双链SV40 DNA中大鼠肝脏和小麦胚芽1型DNA拓扑异构酶断裂位点处的核苷酸序列偏好性。
Nucleic Acids Res. 1984 Apr 11;12(7):3097-114. doi: 10.1093/nar/12.7.3097.