Institute of Food Safety and Quality, Jiangsu Academy of Agricultural Sciences, Nanjing, China.
Int J Mol Sci. 2010 Mar 2;11(3):896-911. doi: 10.3390/ijms11030896.
A bacterial strain EMS with the capability of degrading microcystins (MCs) was isolated from Lake Taihu, China. The bacterium was tentatively identified as a Stenotrophomonas sp. The bacterium could completely consume MC-LR and MC-RR within 24 hours at a concentration of 0.7 microg/mL and 1.7 microg/mL, respectively. The degradation of MC-LR and MC-RR by EMS occurred preferentially in an alkaline environment. In addition, mlrA gene involved in the degradation of MC-LR and MC-RR was detected in EMS. Due to the limited literature this gene has rare homologues. Sequencing analysis of the translated protein from mlrA suggested that MlrA might be a transmembrane protein, which suggests a possible new protease family having unique function.
从中国太湖中分离到一株能够降解微囊藻毒素（MCs）的细菌 EMS。该细菌被初步鉴定为 Stenotrophomonas 属。在 0.7μg/mL 和 1.7μg/mL 的浓度下，细菌能在 24 小时内完全消耗 MC-LR 和 MC-RR。EMS 优先在碱性环境中降解 MC-LR 和 MC-RR。此外，在 EMS 中检测到参与降解 MC-LR 和 MC-RR 的 mlrA 基因。由于文献有限，该基因的同源物很少。mlrA 翻译蛋白的测序分析表明，MlrA 可能是一种跨膜蛋白，这表明可能存在具有独特功能的新型蛋白酶家族。
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