Research team for health benefit of fruit, National Institute of Fruit Tree Science, 485-6 Shimizu-Okitsu-nakachou, Shizuoka-shi, Shizuoka, 424-0292, Japan.
Osteoporos Int. 2011 Jan;22(1):143-52. doi: 10.1007/s00198-010-1239-9. Epub 2010 May 18.
Recent studies show that antioxidants may reduce the risk of osteoporosis. This study showed the associations of bone mineral density with dietary patterns of antioxidant vitamins and carotenoids. The findings suggest the combination of vitamin C and β-cryptoxanthin intakes might provide benefit to bone health in post-menopausal Japanese female subjects.
Recent epidemiological studies show antioxidants may reduce the risk of osteoporosis, but little is known about the dietary patterns of antioxidant vitamin and carotenoid intakes and their relation with bone mineral density (BMD).
A total of 293 post-menopausal female subjects who had received health examinations in the town of Mikkabi, Shizuoka Prefecture, Japan, participated in the study. Radial BMD was measured using dual-energy X-ray absorptiometry. Dietary intakes of antioxidant vitamins and carotenoids were assessed by using a validated food-frequency questionnaire. Dietary patterns were identified on a selected set of antioxidants through principal component factor analysis.
Three dietary patterns were identified. The "retinol" pattern, characterized by notably high intakes of preformed retinol, zeaxanthin, and vitamin E, was positively associated with the risk for low BMD. In contrast, the "β-cryptoxanthin" pattern, characterized by notably high intakes of β-cryptoxanthin and vitamin C, was negatively associated with low BMD. The odds ratios for low BMD in the highest tertiles of dietary intakes of preformed retinol, vitamin C, and β-cryptoxanthin against the lowest tertiles were 3.22 [95% confidence interval (CI), 1.38-7.51], 0.25 (CI, 0.10-0.66), and 0.40 (CI, 0.17-0.92), respectively, after adjustments for confounders. However, negative associations of vitamin C and β-cryptoxanthin with low BMD were not significant after further adjustment for intake of β-cryptoxanthin or vitamin C, respectively. Higher intakes of both vitamin C and β-cryptoxanthin were significantly associated with low BMD (P < 0.05).
The combination of vitamin C and β-cryptoxanthin may be associated with radial BMD in post-menopausal Japanese female subjects.
最近的研究表明，抗氧化剂可能降低骨质疏松症的风险。本研究表明，骨矿物质密度与抗氧化维生素和类胡萝卜素的饮食模式有关。研究结果表明，维生素 C 和β-隐黄质的摄入量结合可能对绝经后日本女性的骨骼健康有益。
最近的流行病学研究表明，抗氧化剂可能降低骨质疏松症的风险，但关于抗氧化维生素和类胡萝卜素的饮食模式及其与骨矿物质密度（BMD）的关系知之甚少。
共有 293 名接受日本静冈县三岛市健康检查的绝经后女性参与了这项研究。使用双能 X 射线吸收法测量桡骨 BMD。通过验证后的食物频率问卷评估抗氧化维生素和类胡萝卜素的饮食摄入量。通过主成分因子分析从一组选定的抗氧化剂中确定饮食模式。
确定了三种饮食模式。“视黄醇”模式的特点是显著高的视黄醇、玉米黄质和维生素 E 摄入量，与低 BMD 风险呈正相关。相比之下，“β-隐黄质”模式的特点是β-隐黄质和维生素 C 的摄入量显著较高，与低 BMD 呈负相关。在最高 tertiles 中，饮食摄入的视黄醇、维生素 C 和β-隐黄质与最低 tertiles 相比，低 BMD 的比值比分别为 3.22 [95%置信区间（CI），1.38-7.51]、0.25（CI，0.10-0.66）和 0.40（CI，0.17-0.92），调整混杂因素后。然而，在进一步分别调整β-隐黄质或维生素 C 的摄入量后，维生素 C 和β-隐黄质与低 BMD 之间的负相关关系不再显著。较高的维生素 C 和β-隐黄质摄入量与低 BMD 显著相关（P<0.05）。
维生素 C 和β-隐黄质的结合可能与绝经后日本女性的桡骨 BMD 有关。
