Dietary Assessment and Epidemiology Research Program, Jean Mayer USDA Human Nutrition Research Center on Aging (HNRCA) and Friedman School of Nutrition Science and Policy (FSNSP), Tufts University, Boston, MA, USA.
Osteoporos Int. 2009 Nov;20(11):1853-61. doi: 10.1007/s00198-009-0897-y. Epub 2009 Apr 4.
Vitamin C may play a role in bone health. In the Framingham Study, subjects with higher total or supplemental vitamin C intake had fewer hip fractures and non-vertebral fractures as compared to subjects with lower intakes. Therefore, vitamin C may have a protective effect on bone health in older adults.
Dietary antioxidants such as vitamin C may play a role in bone health. We evaluated associations of vitamin C intake (total, dietary, and supplemental) with incident hip fracture and non-vertebral osteoporotic fracture, over a 15- to 17-year follow-up, in the Framingham Osteoporosis Study.
Three hundred and sixty-six men and 592 women (mean age 75 +/- 5 years) completed a food frequency questionnaire (FFQ) in 1988-1989 and were followed for non-vertebral fracture until 2003 and hip fracture until 2005. Tertiles of vitamin C intake were created from estimates obtained using the Willett FFQ, after adjusting for total energy (residual method). Hazard ratios were estimated using Cox-proportional hazards regression, adjusting for covariates.
Over follow-up 100 hip fractures occurred. Subjects in the highest tertile of total vitamin C intake had significantly fewer hip fractures (P trend = 0.04) and non-vertebral fractures (P trend = 0.05) compared to subjects in the lowest tertile of intake. Subjects in the highest category of supplemental vitamin C intake had significantly fewer hip fractures (P trend = 0.02) and non-vertebral fractures (P trend = 0.07) compared to non-supplement users. Dietary vitamin C intake was not associated with fracture risk (all P > 0.22).
These results suggest a possible protective effect of vitamin C on bone health in older adults.
维生素 C 可能在骨骼健康中发挥作用。在弗雷明汉研究中，与摄入量较低者相比，总摄入量或补充剂摄入量较高的受试者髋部骨折和非椎骨骨折较少。因此，维生素 C 可能对老年人的骨骼健康有保护作用。
膳食抗氧化剂，如维生素 C，可能在骨骼健康中发挥作用。我们评估了维生素 C 摄入量（总摄入量、膳食摄入量和补充剂摄入量）与 15-17 年随访期间发生髋部骨折和非椎骨骨质疏松性骨折的相关性，该研究纳入了弗雷明汉骨质疏松症研究中的 366 名男性和 592 名女性（平均年龄 75 ± 5 岁）。这些参与者于 1988-1989 年完成了食物频率问卷（FFQ），并随访至 2003 年非椎骨骨折，随访至 2005 年髋部骨折。采用 Willett FFQ 估计值，根据总能量（残差法）调整后，将维生素 C 摄入量分为三部分。使用 Cox 比例风险回归估计风险比，同时调整协变量。
随访期间发生了 100 例髋部骨折。与最低摄入量组相比，总维生素 C 摄入量最高组的髋部骨折（P 趋势=0.04）和非椎骨骨折（P 趋势=0.05）明显减少。与非补充者相比，补充维生素 C 摄入量最高组的髋部骨折（P 趋势=0.02）和非椎骨骨折（P 趋势=0.07）明显减少。膳食维生素 C 摄入量与骨折风险无关（所有 P>0.22）。
这些结果表明，维生素 C 对老年人骨骼健康可能具有保护作用。
