Sundar S, Rajan A G, Somani P N, Kumar K
Department of Medicine, Banaras Hindu University, Varanasi, India.
Acta Cardiol. 1991;46(2):227-35.
Effects of commonly used antihypertensive agents like nifedipine, atenolol, propranolol and captopril on quality of life was studied. Fourty-four patients with essential hypertension entered and 26 completed the full protocol of the study. Each drug was given separately in a random fashion in fixed dosage for 4 weeks with a washout period of 2 weeks in between the drugs. Assessment of quality of life was done under following measures: satisfaction with life and sense of well being, physical state, emotional state, intellectual function, social life and sexual life; each assessed on a prestandardized 5 point scale. All the 4 drugs resulted in significant and similar blood pressure control but the incidence of adverse effects was maximum with nifedipine (40.9%), followed by atenolol (18.4%), propranolol (14.3%) and captopril (3.6%). There was significant improvement in various aspects of quality of life with all the 4 drugs. Captopril and propranolol scored significantly better than atenolol and nifedipine on measures like sense of well being and satisfaction with life, physical state, intellectual function and emotional state. Improvement in sexual life was maximum with captopril, moderate with propranolol and nifedipine and least with atenolol. In conclusion, captopril closely followed by propranolol was the most acceptable drug with fewer adverse effects and improved sexual as well as other aspects of quality of life compared to nifedipine and atenolol.
研究了硝苯地平、阿替洛尔、普萘洛尔和卡托普利等常用抗高血压药物对生活质量的影响。44例原发性高血压患者进入研究，26例完成了完整的研究方案。每种药物以固定剂量随机单独给药4周，药物之间有2周的洗脱期。生活质量评估采用以下指标：对生活的满意度和幸福感、身体状况、情绪状态、智力功能、社会生活和性生活；每项指标均采用预先标准化的5分制进行评估。所有4种药物均能显著且相似地控制血压，但不良反应发生率最高的是硝苯地平（40.9%），其次是阿替洛尔（18.4%）、普萘洛尔（14.3%）和卡托普利（3.6%）。所有4种药物在生活质量的各个方面均有显著改善。在幸福感和生活满意度、身体状况、智力功能和情绪状态等指标上，卡托普利和普萘洛尔的得分明显高于阿替洛尔和硝苯地平。卡托普利对性生活的改善最大，普萘洛尔和硝苯地平中等，阿替洛尔最小。总之，与硝苯地平和阿替洛尔相比，卡托普利紧随普萘洛尔之后是最可接受的药物，不良反应较少，性生活及生活质量的其他方面均有改善。
