Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Am J Gastroenterol. 2010 Jun;105(6):1319-26. doi: 10.1038/ajg.2010.79. Epub 2010 May 18.
Preparation regimens for morning colonoscopy are suboptimal. The aim of this study was to test the efficacy and tolerance of a split-dose magnesium citrate-low-volume (2 liters) polyethylene glycol (PEG) regimen for morning colonoscopy.
A total of 232 patients were randomly assigned to receive 4 liters PEG (day before procedure; group 1, n=79), 2 liters PEG (day before procedure) followed by another 2 liters PEG (day of procedure; group 2, n=80), or magnesium citrate (250 ml, day before procedure) followed by 2 liters PEG (day of procedure; group 3, n=73). The quality of bowel cleansing, tolerability, and adverse effects in group 3 were compared with those in groups 1 and 2.
Satisfactory bowel preparation was more frequently reported for group 3 than for group 1 (75% vs. 51%, P=0.001) and was similar to that for group 2 (75% vs. 76%, P=0.896). A significantly greater proportion of patients in group 3 graded their overall satisfaction as satisfactory compared with group 1 (43% vs. 23%, P=0.010), and the proportion was similar to that in group 2 (43% vs. 35%, P=0.133). Patients in group 3 were more willing to repeat the same preparation regimen, if necessary, than those in group 1 (93% vs. 48%, P<0.001) or group 2 (93% vs. 62%, P<0.001).
The split-dose magnesium citrate-low-volume (2 liters) PEG regimen was more efficient than and preferred to the conventional regimen of 4 liters of PEG, and it was equally efficient as, but, again, preferred to the split-dose (2+2 liters) regimen for morning colonoscopy.
用于早晨结肠镜检查的准备方案并不理想。本研究的目的是测试镁柠檬酸-低容量（2 升）聚乙二醇（PEG）方案在早晨结肠镜检查中的疗效和耐受性。
共有 232 名患者被随机分配接受 4 升 PEG（检查前一天；第 1 组，n=79）、2 升 PEG（检查前一天）加 2 升 PEG（检查当天；第 2 组，n=80）或镁柠檬酸（250 毫升，检查前一天）加 2 升 PEG（检查当天；第 3 组，n=73）。第 3 组的肠道清洁质量、耐受性和不良反应与第 1 组和第 2 组进行了比较。
第 3 组报告的肠道准备满意度明显高于第 1 组（75%比 51%，P=0.001），与第 2 组相似（75%比 76%，P=0.896）。第 3 组患者中，有更多的患者对整体满意度评价为满意，而第 1 组（43%比 23%，P=0.010），且比例与第 2 组相似（43%比 35%，P=0.133）。第 3 组患者如果需要，更愿意重复相同的准备方案，而第 1 组（93%比 48%，P<0.001）或第 2 组（93%比 62%，P<0.001）。
与 4 升 PEG 相比，镁柠檬酸-低容量（2 升）PEG 方案更有效且更受患者欢迎，与 2+2 升 PEG 方案相比，其效率相同，但也更受患者欢迎，用于早晨结肠镜检查。
