The First Hospital of Jilin University, Changchun, Jilin, China.
Can J Gastroenterol Hepatol. 2022 Aug 31;2022:8169649. doi: 10.1155/2022/8169649. eCollection 2022.
A total of 120 patients were randomized to receive either the control group ( = 64) or the experimental group ( = 65). Patients in the control group adopted the low-volume split-dose regimen one, and patients in the experimental group adopted the low-volume split-dose regimen two. Those randomized to regimen one were instructed to take 0.75 L PEG two hours after dinner the day before the colonoscopy and 1.5 L PEG 4 hours before the colonoscopy. Patients assigned to regimen two were invited to consume 1.5 L PEG two hours after dinner the day before the colonoscopy and 0.75 L PEG 4 hours before the colonoscopy. The quality of bowel preparation, rated according to a Boston Bowel Preparation Scale (BBPS), represented the primary outcome measure. Tolerability, satisfaction, and lesions detection rated were secondary outcomes.
There was no significant difference between the transverse colon and right colon scores between the two groups ( > 0.05). The low-volume split-dose regimen two showed a higher success rate for cleansing of the right colon and overall colon ( < 0.05). For the comparison of the patients' bowel tolerance, there were no statistical differences between the two groups regarding thirst, abdominal pain or abdominal discomfort, abdominal distension, dizziness or headache, anal discomfort, and sleep disturbance ( > 0.05). However, regimen two had significantly less nausea, vomiting, and fatigue than regimen one (24.62% vs. 42.19%, =0.034; 10.77% vs. 25.00%, =0.035; 6.15% vs. 21.88%, =0.010, respectively). Patient-reported satisfaction and willingness to repeat the bowel preparation were significantly higher for low-volume split-dose regimen two than for low-volume split-dose regimen one (=0.011; =0.015).
In early morning colonoscopies, the bowel-cleansing efficacy and patient tolerability of low-volume split-dose regimen two were superior to low-volume split-dose regimen one.
将 120 例患者随机分为对照组（n=64）和实验组（n=65）。对照组采用低容量分次方案一，实验组采用低容量分次方案二。方案一的患者被指示在结肠镜检查前一天晚餐后两小时服用 0.75L PEG，在结肠镜检查前 4 小时服用 1.5L PEG。方案二的患者被邀请在结肠镜检查前一天晚餐后两小时服用 1.5L PEG，在结肠镜检查前 4 小时服用 0.75L PEG。肠道准备质量，根据波士顿肠道准备量表（BBPS）评分，作为主要观察指标。耐受性、满意度和病变检出率为次要观察指标。
两组横结肠和右半结肠评分无显著差异（>0.05）。低容量分次方案二在右半结肠和全结肠清洁成功率方面表现更高（<0.05）。在患者肠道耐受性比较方面，两组口渴、腹痛或腹部不适、腹胀、头晕或头痛、肛门不适和睡眠障碍无统计学差异（>0.05）。然而，方案二的恶心、呕吐和疲劳发生率明显低于方案一（24.62%比 42.19%，=0.034；10.77%比 25.00%，=0.035；6.15%比 21.88%，=0.010）。低容量分次方案二的患者报告满意度和愿意重复肠道准备的意愿明显高于低容量分次方案一（=0.011；=0.015）。
在清晨结肠镜检查中，低容量分次方案二的肠道清洁效果和患者耐受性优于低容量分次方案一。
