Liang Tong, Wang Junhong, Gao Zhenhua, Da Mingxu
The First School of Clinical Medicine, Lanzhou University, Lanzhou, Gansu, 730000, China.
Department of Surgical Oncology, Gansu Provincial Hospital, Lanzhou, Gansu, 730000, China.
Comb Chem High Throughput Screen. 2025;28(2):254-262. doi: 10.2174/0113862073290567240506162553.
Metabolic syndrome (MetS) is a cluster of cardiovascular risk factors, including abdominal obesity, hyperglycemia, hypertension, and dyslipidemia. Gastric cancer (GC) is a common malignancy with significant mortality rates. The relationship between MetS and GC risk remains controversial. This systematic review and meta-analysis aimed to evaluate the correlation between MetS and GC.
Case-control studies investigating the association between MetS and GC were obtained from various databases, including China National Knowledge Infrastructure (CNKI), SinoMed, Embase, Web of Science, The Cochrane Library, and PubMed. The search was performed from the inception of each database up until September, 2023. Two researchers independently screened the literature, extracted data, and assessed the quality of the included studies. A meta-analysis of the included literature was conducted using Stata 12.0 software. The study protocol is registered in PROSPERO (CRD42023490410).
A total of eight studies involving a combined sample size of forty-four thousand eight hundred and seventy participants were included in the meta-analysis. The findings revealed that the risk of developing GC was not significantly associated with body mass index, triglycerides, hypertension, high fasting glucose, or MetS. However, it was found to be positively correlated with high-density lipoprotein cholesterol (OR = 1.69, 95%CI: 1.35-2.12).
This meta-analysis suggests that MetS is not significantly associated with an increased risk of GC. The risk of GC increases with the presence of individual MetS components, such as high-density lipoprotein cholesterol. Therefore, GC prevention strategies should include lifestyle modifications and targeted interventions to manage MetS and its components.
代谢综合征（MetS）是一组心血管危险因素，包括腹型肥胖、高血糖、高血压和血脂异常。胃癌（GC）是一种常见的恶性肿瘤，死亡率很高。MetS与GC风险之间的关系仍存在争议。本系统评价和荟萃分析旨在评估MetS与GC之间的相关性。
从多个数据库中获取调查MetS与GC之间关联的病例对照研究，包括中国知网（CNKI）、中国生物医学文献数据库（SinoMed）、Embase、科学引文索引（Web of Science）、考克兰图书馆（The Cochrane Library）和医学期刊数据库（PubMed）。检索从每个数据库建立之初至2023年9月进行。两名研究人员独立筛选文献、提取数据并评估纳入研究的质量。使用Stata 12.0软件对纳入文献进行荟萃分析。该研究方案已在国际前瞻性系统评价注册库（PROSPERO）中注册（注册号：CRD42023490410）。
荟萃分析共纳入八项研究，合并样本量为四万四千八百七十名参与者。研究结果显示，患GC的风险与体重指数、甘油三酯、高血压、空腹血糖升高或MetS无显著关联。然而，发现其与高密度脂蛋白胆固醇呈正相关（比值比=1.69，95%置信区间：1.35-2.12）。
这项荟萃分析表明，MetS与GC风险增加无显著关联。GC风险随着MetS的个体组成成分如高密度脂蛋白胆固醇的出现而增加。因此，GC预防策略应包括生活方式改变以及针对MetS及其组成成分的靶向干预措施。
