Division of Gastroenterology, Department of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.
Gut Liver. 2007 Jun;1(1):63-7. doi: 10.5009/gnl.2007.1.1.63. Epub 2007 Jun 30.
BACKGROUND/AIMS: Obstruction of the main pancreatic duct (MPD) has been considered one of the major causes for pain in chronic pancreatitis (CP). In this study, we evaluated the efficacy of MPD stenting in painful CP, and tried to determine a guideline for stent removal.
Sixteen patients with painful CP who underwent MPD stenting were included. Follow up ERCP was performed 3 months after stenting in all patients. Stents were removed in patients who achieved pain relief, complete stone clearance, and decreased MPD diameter after 3 months.
Before stenting, ERCP showed MPD stricture in 11 cases, MPD dilatation by stone in 1 case, concomitant stricture and stone in 4 cases. After stenting, complete pain relief was achieved in 13 patients (81.3%) and partial pain relief was achieved in 3 patient (18.7%). There was no patient whose pain was not relieved. Stents were removed in 7 patients who achieved pain relief, complete stone clearance, and decreased MPD diameter after 3 months. Decrease of MPD diameter was significantly greater in patient who could remove stent than those who could not (72.9% vs. 127.9% of initial MPD diameter, p=0.008).
If partial or full pain relief is achieved after MPD stenting and follow up ERCP after 3 months shows decreased MPD diameter compared to the initial one, stent removal might be considered.
背景/目的:主胰管(MPD)阻塞被认为是慢性胰腺炎(CP)疼痛的主要原因之一。在本研究中,我们评估了 MPD 支架置入术治疗 CP 疼痛的疗效,并试图确定支架取出的指南。
纳入 16 例接受 MPD 支架置入术的 CP 疼痛患者。所有患者在支架置入后 3 个月进行随访 ERCP。在 3 个月后疼痛缓解、完全清除结石和 MPD 直径减小的患者中取出支架。
支架置入前,ERCP 显示 11 例 MPD 狭窄,1 例 MPD 结石扩张,4 例同时存在狭窄和结石。支架置入后,13 例患者(81.3%)完全缓解疼痛,3 例患者(18.7%)部分缓解疼痛。没有患者疼痛未缓解。在 3 个月后疼痛缓解、完全清除结石和 MPD 直径减小的 7 例患者中取出了支架。与初始 MPD 直径相比,能够取出支架的患者 MPD 直径减小更为显著(72.9%比初始 MPD 直径减少 127.9%,p=0.008)。
如果 MPD 支架置入后出现部分或完全缓解疼痛,并且 3 个月后的随访 ERCP 显示 MPD 直径比初始时减小,则可以考虑取出支架。