Division of Gastroenterology and Hepatology, Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan.
J Clin Lab Anal. 2010;24(3):195-200. doi: 10.1002/jcla.20320.
Deregulation of insulin-like growth factor-1 (IGF-1) has been implicated in the pathogenesis of several malignancies. This study aimed to investigate the association of changes in circulating IGF-1 with hepatocellular carcinoma (HCC). The radioimmunoassay was used to analyze serum IGF-1 levels of 65 HCC patients and 165 healthy subjects. Serum IGF-1 levels were significantly decreased in the HCC patients as compared with the healthy subjects (158.46+/-105.07 vs. 247.63+/-149.96 ng/mL, P<0.001). Furthermore, insulin resistance was significantly higher in the HCC patients than the healthy subjects (P=0.027). In addition, the significant correlations of serum IGF-1 levels with age and insulin resistance in the healthy subjects were not noted in the HCC patients. Intriguingly, individuals with hepatitis C virus (HCV), not hepatitis B virus, had remarkably decreased IGF-1 levels in both groups of the HCC patients and healthy subjects. Moreover, in the HCV subgroup, serum IGF-1 levels were significantly reduced in the HCC patients than the healthy subjects (113.14+/-71.28 vs. 172.42+/-74.02 ng/mL, P=0.003). In conclusion, decreased serum IGF-1 levels were associated with HCC and the decrease was remarkably noted in those patients concomitant with chronic hepatitis C.
胰岛素样生长因子-1（IGF-1）的失调与多种恶性肿瘤的发病机制有关。本研究旨在探讨循环 IGF-1 变化与肝细胞癌（HCC）的关系。采用放射免疫分析法分析 65 例 HCC 患者和 165 例健康对照者的血清 IGF-1 水平。与健康对照组相比，HCC 患者的血清 IGF-1 水平显著降低（158.46+/-105.07 与 247.63+/-149.96ng/mL，P<0.001）。此外，HCC 患者的胰岛素抵抗明显高于健康对照组（P=0.027）。此外，在健康对照组中，血清 IGF-1 水平与年龄和胰岛素抵抗呈显著相关，但在 HCC 患者中未观察到这种相关性。有趣的是，在 HCC 患者和健康对照者两组中，HCV 而非 HBV 个体的 IGF-1 水平均显著降低。此外，在 HCV 亚组中，HCC 患者的血清 IGF-1 水平明显低于健康对照组（113.14+/-71.28 与 172.42+/-74.02ng/mL，P=0.003）。总之，血清 IGF-1 水平降低与 HCC 相关，在伴有慢性丙型肝炎的患者中降低更为明显。
