Institut und Poliklinik für Arbeits- und Sozialmedizin, Justus-Liebig-Universität, Aulweg 129, D-35392 Giessen, Germany.
Biomarkers. 2010 Aug;15(5):400-9. doi: 10.3109/1354750X.2010.481365.
Tumour necrosis factor (TNF)-alpha influences the pathogenesis of lung fibrosis and carcinogenesis in normal cells. Polymorphisms of this gene have been suggested to be associated with susceptibility to lung diseases.
Association studies were performed in German subjects, using control subjects (n = 177), pulmonary fibrosis patients (n = 612) and bronchial carcinoma patients (n = 374).
Compared with a healthy (control) group, a significant result could be obtained for the asbestosis (patient) group (crude odds ratio (OR(crude)) = 1.57; 95% confidence interval (CI) 1.05-2.36; p = 0.03), especially with severe lung asbestosis (OR(crude) = 4.15; 95% CI 1.06-16.16; p = 0.04). A significant association was revealed when comparing asbestosis patients (OR(crude) = 4.08; 95% CI 1.53-10.54; p = 0.004 and OR(adjusted) = 3.89; 95% CI 1.49-10.17; p = 0.006) with asbestos-induced lung cancer patients.
The results confirm the hypothesis that TNF-alpha polymorphisms are associated with asbestos-induced fibrotic or malignant lung diseases in Germans.
肿瘤坏死因子（TNF）-α影响肺纤维化和正常细胞癌变的发病机制。该基因的多态性与肺部疾病的易感性有关。
使用对照受试者（n=177）、特发性肺纤维化患者（n=612）和支气管癌患者（n=374），在德国受试者中进行了关联研究。
与健康（对照）组相比，石棉肺（患者）组的结果具有显著意义（粗比值比（OR（粗））=1.57；95%置信区间（CI）1.05-2.36；p=0.03），尤其是严重肺石棉肺（OR（粗）=4.15；95%CI 1.06-16.16；p=0.04）。当比较石棉肺患者（OR（粗）=4.08；95%CI 1.53-10.54；p=0.004 和 OR（调整）=3.89；95%CI 1.49-10.17；p=0.006）与石棉引起的肺癌患者时，发现了显著的相关性。
这些结果证实了 TNF-α 多态性与德国人群中石棉引起的纤维性或恶性肺部疾病相关的假设。
