Zhou Wei, Zhang Shuxiang, Hu Yingchun, Na Jianrong, Wang Na, Ma Xuan, Yuan Lizhi, Meng Fanzhen
Department of Respiration, General Hospital of Ningxia Medical University, Shengli Street, Yinchuan, 750004, China.
Eur J Med Res. 2015 Mar 21;20(1):28. doi: 10.1186/s40001-015-0113-9.
Several studies have indicated an association between tumor necrosis factor-alpha (TNF-α) or interleukin (IL)-6 gene polymorphisms and lung cancer risk. However, the conclusions remain controversial.
An English literature screening about case-control trials with regard to TNF-α (-308G/A) or IL-6 (174G/C) polymorphisms and lung cancer susceptibility was performed on PubMed, EMBASE, and EBSCO until November 2012. The pooled odds ratio (OR) and 95% confidence intervals (CI) were calculated using STATA 11.0. Sensitivity analysis was performed by sequential omission of individual studies. Publication bias was evaluated by Egger's linear regression test and funnel plots.
Eight eligible studies, including 1,690 patients and 1,974 controls, were identified in this meta-analysis. Compared with the control, no significant association was revealed between TNF-α-308G/A (GG + GC vs. CC: OR = 1.10, 95% CI: 0.73 to 1.64; GG vs. GC + CC: OR = 1.02, 95% CI: 0.81 to 1.27; GC vs. CC: OR = 1.13, 95% CI: 0.73 to 1.77; GG vs. CC: OR = 1.04, 95% CI: 0.80 to 1.36; G vs. C: OR = 1.03, 95% CI: 0.90 to 1.18) or IL-6 174G/C (GG + GC vs. CC: OR = 1.10, 95% CI: 0.73 to 1.64; GG vs. GC + CC: OR = 1.02, 95% CI: 0.81 to 1.27; GC vs. CC: OR = 1.13, 95% CI: 0.73 to 1.77; GG vs. CC: OR = 1.04, 95% CI: 0.80 to 1.36; G vs. C: OR = 1.03, 95% CI: 0.90 to 1.18) and lung cancer risk. The pooled OR remained unchanged after removing the maximum-weight study and no publication bias was observed.
The study raises the possibility of no correlation between the polymorphisms of the two genes and lung cancer susceptibility. However, further researches with large-sample or subgroup analyses are necessary to validate the conclusions.
多项研究表明肿瘤坏死因子-α（TNF-α）或白细胞介素（IL）-6基因多态性与肺癌风险之间存在关联。然而，结论仍存在争议。
截至2012年11月，在PubMed、EMBASE和EBSCO上对关于TNF-α（-308G/A）或IL-6（174G/C）多态性与肺癌易感性的病例对照试验进行英文文献筛选。使用STATA 11.0计算合并比值比（OR）和95%置信区间（CI）。通过逐个剔除个别研究进行敏感性分析。通过Egger线性回归检验和漏斗图评估发表偏倚。
该荟萃分析纳入了8项符合条件的研究，包括1690例患者和1974例对照。与对照组相比，TNF-α -308G/A（GG + GC vs. CC：OR = 1.10，95% CI：0.73至1.64；GG vs. GC + CC：OR = 1.02，95% CI：0.81至1.27；GC vs. CC：OR = 1.13，95% CI：0.73至1.77；GG vs. CC：OR = 1.04，95% CI：0.80至1.36；G vs. C：OR = 1.03，95% CI：0.90至1.18）或IL-6 174G/C（GG + GC vs. CC：OR = 1.10，95% CI：0.73至1.64；GG vs. GC + CC：OR = 1.02，95% CI：0.81至1.27；GC vs. CC：OR = 1.13，95% CI：0.73至1.77；GG vs. CC：OR = 1.04，95% CI：0.80至1.36；G vs. C：OR = 1.03，95% CI：0.90至1.18）与肺癌风险之间未显示出显著关联。剔除权重最大的研究后，合并OR保持不变，且未观察到发表偏倚。
该研究提出这两个基因的多态性与肺癌易感性之间可能不存在相关性。然而，需要进一步进行大样本或亚组分析研究以验证这些结论。
