止泻药在体外和体内的阿片类激动剂作用——支持选择性作用的研究结果 - Suppr

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超能文献

Opiate agonist action of antidiarrheal agents in vitro and in vivo--findings in support for selective action.

作者信息

Wüster M, Herz A

出版信息

Naunyn Schmiedebergs Arch Pharmacol. 1978 Jan-Feb;301(3):187-94. doi: 10.1007/BF00507036.

DOI:10.1007/BF00507036

PMID:204876

Abstract

摘要

相似文献

Opiate agonist action of antidiarrheal agents in vitro and in vivo--findings in support for selective action.止泻药在体外和体内的阿片类激动剂作用——支持选择性作用的研究结果

Naunyn Schmiedebergs Arch Pharmacol. 1978 Jan-Feb;301(3):187-94. doi: 10.1007/BF00507036.

Antidiarrheal and central nervous system activities of SC-27166 (2-[3 - 5 - methyl - 1, 3, 4 - oxadiazol - 2 - yl) - 3, 3 - diphenylpropyl] - 2 - azabicyclo [2.2.2]octane), a new antidiarrheal agent, resulting from binding to opiate receptor sites of brain and myenteric plexus.新型止泻药SC-27166（2-[3 - 5 - 甲基 - 1, 3, 4 - 恶二唑 - 2 - 基)-3, 3 - 二苯基丙基]-2 - 氮杂双环[2.2.2]辛烷）的止泻及中枢神经系统活性，源于其与脑和肌间神经丛的阿片受体位点结合。

J Pharmacol Exp Ther. 1977 Dec;203(3):527-38.

Interaction of loperamide with [3H]naloxone binding sites in guinea pig brain and myenteric plexus.洛哌丁胺与豚鼠脑和肠肌丛中[³H]纳洛酮结合位点的相互作用。

Mol Pharmacol. 1977 May;13(3):533-40.

Loperamide binding to opiate receptor sites of brain and myenteric plexus.洛哌丁胺与脑和肌间神经丛的阿片受体位点结合。

J Pharmacol Exp Ther. 1976 Oct;199(1):131-40.

Dextrorphan binds to opioid receptors in guinea-pig brain membranes and is an antagonist at opioid receptors in myenteric plexus.右啡烷与豚鼠脑膜中的阿片受体结合，并且是肠肌丛中阿片受体的拮抗剂。

Proc Natl Acad Sci U S A. 1990 Mar;87(5):1629-32. doi: 10.1073/pnas.87.5.1629.

Opiate receptor mediation of ketamine analgesia.氯胺酮镇痛的阿片受体介导作用。

Anesthesiology. 1982 Apr;56(4):291-7. doi: 10.1097/00000542-198204000-00011.

Pharmacology of antidiarrheal drugs.止泻药的药理学

Annu Rev Pharmacol Toxicol. 1983;23:279-301. doi: 10.1146/annurev.pa.23.040183.001431.

Dissociation between opiate-like and antidiarrheal activities of antidiarrheal drugs.止泻药的阿片样活性与止泻活性之间的解离。

J Pharmacol Exp Ther. 1979 Sep;210(3):327-33.

Assessment of the potential agonistic and antagonistic properties of ketamine at opiate receptors in the guinea-pig ileum.氯胺酮对豚鼠回肠阿片受体潜在激动和拮抗特性的评估。

Neuropharmacology. 1982 Jul;21(7):605-11. doi: 10.1016/0028-3908(82)90001-6.

Effect of morphine on serotonin release from myenteric plexus of the guinea pig.吗啡对豚鼠肠肌丛5-羟色胺释放的影响。

J Pharmacol Exp Ther. 1974 Sep;190(3):420-30.

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Difenoxin and loperamide: studies on possible mechanisms of intestinal antisecretory action.地芬诺辛与洛哌丁胺：肠道抗分泌作用可能机制的研究

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Unexpected prosecretory action component of loperamide at mu-opioid receptors in the guinea-pig colonic mucosa in vitro.洛哌丁胺在豚鼠结肠黏膜μ-阿片受体上的体外意外促分泌作用成分。

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Response pattern of visceral afferent fibres, supplying the colon, upon chemical and mechanical stimuli.供应结肠的内脏传入纤维对化学和机械刺激的反应模式。

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Local inhibition of myoelectrical activity of human colon by loperamide.洛哌丁胺对人结肠肌电活动的局部抑制作用。

Dig Dis Sci. 1984 Mar;29(3):232-8. doi: 10.1007/BF01296257.

Loperamide in acute diarrhoea in childhood: results of a double blind, placebo controlled multicentre clinical trial. Diarrhoeal Diseases Study Group (UK).洛哌丁胺治疗儿童急性腹泻：一项双盲、安慰剂对照的多中心临床试验结果。腹泻病研究组（英国）

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本文引用的文献

Synthetic antidiarrhoeal agents--I. Some pharmacological properties of R 1132 and related compounds.合成止泻剂——I. R 1132及相关化合物的一些药理学特性。

J Med Pharm Chem. 1959 Aug;1:299-308. doi: 10.1021/jm50005a001.

STIMULANT ACTIONS OF VOLATILE ANAESTHETICS ON SMOOTH MUSCLE.挥发性麻醉药对平滑肌的兴奋作用

Br J Pharmacol Chemother. 1964 Apr;22(2):356-65. doi: 10.1111/j.1476-5381.1964.tb02040.x.

Differential response of longitudinal and circular muscles of intact canine colon to morphine and bethanechol.完整犬结肠纵行肌和环行肌对吗啡和氨甲酰甲胆碱的不同反应。

Gastroenterology. 1971 Mar;60(3):438-44.

Difenoxine (R15403), the active metabolite of diphenoxylate (R1132). 1. The excretion and metabolism in rats of difenoxine, the pharmacologically active metabolite of the antidiarrheal agent diphenoxylate.地芬诺辛（R15403），是地芬诺酯（R1132）的活性代谢产物。1. 抗腹泻药地芬诺酯的药理活性代谢产物地芬诺辛在大鼠体内的排泄与代谢。

Arzneimittelforschung. 1972 Mar;22(3):513-6.

Physiochemical properties, solubility, and protein binding of delta9-tetrahydrocannabinol.δ9-四氢大麻酚的物理化学性质、溶解度及蛋白质结合情况

J Pharm Sci. 1974 Jul;63(7):1056-64. doi: 10.1002/jps.2600630705.

Synthetic antidiarrheal agents. 2,2-Diphenyl-4-(4'-aryl-4'-hydroxypiperidino)butyramides.合成止泻剂。2,2-二苯基-4-(4'-芳基-4'-羟基哌啶基)丁酰胺。

J Med Chem. 1973 Jul;16(7):782-6. doi: 10.1021/jm00265a009.

Opiate receptor: demonstration in nervous tissue.阿片受体：在神经组织中的显示

Science. 1973 Mar 9;179(4077):1011-4. doi: 10.1126/science.179.4077.1011.

Effect of 6-hydroxydopamine, 5,6-dihydroxytryptamine and raphe lesions on the antinociceptive actions of morphine in rats.6-羟基多巴胺、5,6-二羟基色胺和中缝核损伤对大鼠吗啡镇痛作用的影响。

Psychopharmacologia. 1973 Jul 17;31(2):111-9. doi: 10.1007/BF00419811.

Loperamide (R 18 553), a novel type of antidiarrheal agent. Part 5: the pharmacokinetics of loperamide in rats and man.洛哌丁胺（R 18 553），一种新型止泻剂。第5部分：洛哌丁胺在大鼠和人体中的药代动力学。

Arzneimittelforschung. 1974 Oct;24(10):1649-53.

Opiate agonists and antagonists discriminated by receptor binding in brain.通过大脑中的受体结合来区分的阿片类激动剂和拮抗剂。

Science. 1973 Dec 28;182(4119):1359-61. doi: 10.1126/science.182.4119.1359.

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