Legay C, Faudon M, Héry F, Ternaux J P
INSERM-U.6 and CNRS-GR.45, 280 Bd Sainte-Marguerite, 13009 Marseille, France.
Neurochem Int. 1983;5(6):721-7. doi: 10.1016/0197-0186(83)90097-9.
Serotonin (5-HT) metabolism was studied on isolated mucosa of the rat caecum in order to determine its characteristics in enterochromaffin cells. High levels of 5-HT were found in these cells and weak catabolic processes were demonstrated. Enterochromaffin cells of the mucosa are able to synthesize ((3)H)5-HT from ((3)H)tryptophan in vitro indicating that these cells might contain tryptophan hydroxylase. In addition, a high affinity uptake of exogenous ((3)H)5-HT is demonstrated. These results show that enterochromaffin cells of the mucosa present similar biochemical properties compared to those described for serotoninergic neurons of the central nervous system.
为了确定大鼠盲肠孤立黏膜中肠嗜铬细胞的5-羟色胺（5-HT）代谢特征，对其进行了研究。在这些细胞中发现了高水平的5-HT，并证实了其微弱的分解代谢过程。黏膜中的肠嗜铬细胞能够在体外从（³H）色氨酸合成（³H）5-HT，这表明这些细胞可能含有色氨酸羟化酶。此外，还证实了对外源性（³H）5-HT的高亲和力摄取。这些结果表明，黏膜中的肠嗜铬细胞与中枢神经系统中5-羟色胺能神经元所描述的具有相似的生化特性。
