University Hospital Marqués de Valdecilla, IFIMAV, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain.
Psychiatry Res. 2010 Jun 30;182(3):216-22. doi: 10.1016/j.pscychresns.2010.03.001. Epub 2010 May 20.
Overall and regional cortical thinning has been observed at the first break of schizophrenia. Due to the fact that structural abnormalities in the insular cortex have been described in schizophrenia, we investigated insular thickness anomalies in first episode schizophrenia. Participants comprised 118 schizophrenia patients and 83 healthy subjects. Magnetic resonance imaging brain scans (1.5T) were obtained, and images were analyzed by using BRAINS2. The contribution of sociodemographic, cognitive and clinical characterictics was controlled. Schizophrenia patients demonstrated a significant right insular thinning, and a significant group by gender interaction was found for left insular thickness. Post-hoc comparisons revealed that male schizophrenia patients had a significant left insular thinning compared with healthy male subjects. There were no significant associations between insular thickness, the severity of symptoms at baseline and cognitive measurements and premorbid variables. The fact that insular thinning is already present at early phases of the illness and is independent of intervening variables offers evidence for the potential of these changes to be a biological marker of the illness.
整体和区域性皮质变薄在精神分裂症的首次发作时就已经观察到。由于在精神分裂症中已经描述了脑岛皮质的结构异常，我们研究了首发精神分裂症的脑岛厚度异常。参与者包括 118 名精神分裂症患者和 83 名健康受试者。获得了磁共振成像脑扫描（1.5T），并使用 BRAINS2 分析图像。控制了社会人口统计学、认知和临床特征的影响。精神分裂症患者表现出右侧脑岛变薄，左侧脑岛厚度存在显著的性别组间交互作用。事后比较显示，与健康男性受试者相比，男性精神分裂症患者的左侧脑岛明显变薄。脑岛厚度与基线时症状的严重程度、认知测量和病前变量之间没有显著相关性。脑岛变薄在疾病的早期阶段就已经存在，并且与干预变量无关，这为这些变化可能成为疾病的生物学标志物提供了证据。
