用于非侵入式近红外荧光成像的花菁染料 7 标记的嗜中性粒细胞特异性试剂的合成。
Synthesis of the Cyanine 7 labeled neutrophil-specific agents for noninvasive near infrared fluorescence imaging.
机构信息
Department of Radiology, The University of Virginia, Charlottesville, VA 22908, USA.
出版信息
Bioorg Med Chem Lett. 2010 Jun 15;20(12):3515-7. doi: 10.1016/j.bmcl.2010.04.136. Epub 2010 May 18.
PMID:20488705
Abstract
A neutrophil-binding peptide, cinnamoyl-F(D)LF(D)LF (cFLFLF), was labeled with the near infrared (NIR) fluorophore, Cyanine 7 (Cy7). This construct was modified with a polyethylene glycol (PEG, M(W) 3.4 kDa) moiety in order to increase its solubility and bioavailability to circulating neutrophils. A preliminary noninvasive fluorescence imaging of a mouse model of ear inflammation with the fluorescent probe is presented.
摘要
一种中性粒细胞结合肽，肉桂酰-F(D)LF(D)LF（cFLFLF），被近红外（NIR）荧光团Cy7 标记。该构建体用聚乙二醇（PEG，M（W）3.4 kDa）部分进行了修饰，以提高其在循环中性粒细胞中的溶解度和生物利用度。本文介绍了用荧光探针对耳炎小鼠模型进行初步的非侵入性荧光成像。
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