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氨基脲、硫代氨基脲及其金属配合物广泛的药理学多样性。

The wide pharmacological versatility of semicarbazones, thiosemicarba-zones and their metal complexes.

作者信息

Beraldo Heloisa, Gambino Dinorah

机构信息

Departamento de Química, Universidade Federal de Minas Gerais, 31270-901, Belo Horizonte, MG, Brazil.

出版信息

Mini Rev Med Chem. 2004 Jan;4(1):31-9. doi: 10.2174/1389557043487484.

DOI:10.2174/1389557043487484
PMID:14754441
Abstract

The more significant bioactivities of a variety of semicarbazones (anti-protozoa, anticonvulsant) and thiosemicarbazones (antibacterial, antifungal, antitumoral, antiviral) and their metal complexes are reviewed together with proposed mechanisms of action and structure-activity relationships. Clinical or potential pharmacological applications of these versatile compounds are discussed.

摘要

综述了多种氨基脲（抗原生动物、抗惊厥）和氨基硫脲（抗菌、抗真菌、抗肿瘤、抗病毒）及其金属配合物的更显著生物活性，以及提出的作用机制和构效关系。讨论了这些多功能化合物的临床或潜在药理学应用。

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