Instituto de Neurociencias, Centro de Investigaciones Biomédicas (CIBM), Universidad de Granada, Granada, Spain.
Rheumatol Int. 2011 Dec;31(12):1555-9. doi: 10.1007/s00296-010-1521-3. Epub 2010 May 20.
Fibromyalgia is a complex and heterogeneous disease, and several attempts have been made in order to identify different subgroups of patients sharing a common symptomatology. The purpose of the present study has been to replicate a subgroup classification proposed by de Souza et al. based in the Fibromyalgia Impact Questionnaire (FIQ) in a large sample of patients with a cultural and clinical setting different from the original one. Four hundred twenty-one patients were classified, according to the results of the visual analog FIQ subscales in type I o type II subgroups. Demographic and clinical data, as well as results of scales assessing disease's severity, quality of life, sleep quality, anxiety and depression, were compared between the two groups. The profiles of type I and type II patients from our sample strikingly paralleled those of the original study, demonstrating the reproducibility of the classification. In our sample, 18.8% of the patients appertained to type I subgroup and 81.2% to type II subgroup. Patients from this later subgroup had higher comorbidity and received more drugs than those of the former. They were also more physically ill, with higher FIQ total scores and worse sleep quality, and more psychologically distressed, with higher levels of anxiety and depression and lower scores in the mental component summary of the Short-Form Health Questionnaire (SF-12). Our study shows that the proposed fibromyalgia classification is reliable and easy to perform and could be applied in further studies.
纤维肌痛是一种复杂且异质的疾病，人们已经尝试了多种方法来识别具有共同症状的不同患者亚组。本研究旨在复制 de Souza 等人基于纤维肌痛影响问卷 (FIQ) 提出的亚组分类方法，该方法应用于具有与原始分类不同的文化和临床背景的大量患者。根据视觉模拟 FIQ 子量表的结果，将 421 名患者分为 I 型或 II 型亚组。比较了两组之间的人口统计学和临床数据，以及评估疾病严重程度、生活质量、睡眠质量、焦虑和抑郁的量表结果。我们样本中 I 型和 II 型患者的特征与原始研究非常相似，证明了分类的可重复性。在我们的样本中，18.8%的患者属于 I 型亚组，81.2%的患者属于 II 型亚组。与前者相比，后者患者的合并症更多，服用的药物也更多。他们的身体状况也更差，FIQ 总分更高，睡眠质量更差，心理困扰也更严重，焦虑和抑郁水平更高，SF-12 心理健康成分简表得分更低。我们的研究表明，所提出的纤维肌痛分类方法可靠且易于实施，可应用于进一步的研究。
