真菌来源的螺双萘并[1,2-b:1',2'-e]呋喃及其生物活性。
Spirobisnaphthalenes from fungi and their biological activities.
机构信息
Department of Plant Pathology, College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, China.
出版信息
Mini Rev Med Chem. 2010 Sep;10(10):977-89. doi: 10.2174/138955710792007178.
Spirobisnaphthalenes have a unique structural feature involving two or three oxygen atoms acting as bridges connecting two original naphthalene subunits. Most of these metabolites isolated from fungi exhibit significant antifungal, antibacterial and cytotoxic properties to show great potential applications in medicine and agriculture. This review focuses on their structural characters and biological activities, as well as their structure-activity relationship, mechanism of action, synthesis and biosynthesis.
螺环二萘并[1,2-b:1',2'-e]呋喃类化合物具有独特的结构特征，涉及两个或三个氧原子作为桥梁，连接两个原始萘基亚基。这些从真菌中分离得到的代谢产物大多数具有显著的抗真菌、抗菌和细胞毒性活性，显示出在医学和农业领域的巨大应用潜力。本文重点介绍了它们的结构特征和生物活性，以及它们的构效关系、作用机制、合成和生物合成。
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