Majhi Sasadhar
Department of Chemistry (UG and PG Department), Triveni Devi Bhalotia College, Kazi Nazrul University, Raniganj, 713347, West Bengal, India.
Photochem Photobiol Sci. 2021 Oct;20(10):1357-1378. doi: 10.1007/s43630-021-00100-3. Epub 2021 Sep 18.
Natural products and their analogue have played a key role in the drug discovery and development process. In the laboratory, the total synthesis of secondary metabolites is very useful in ascertaining the hypothetical complex structure of molecules of natural origin. Total synthesis of natural products using Norrish type I and II reactions as a crucial step has been explored in this overview. Norrish reactions are important photo-induced transformations of carbonyl compounds in organic synthetic chemistry and are connected in numerous industrially and biologically relevant procedures and the processing of carbonyl compounds in the atmosphere. The present review tries to focus on the brilliant applications of Norrish type I and II photochemical reactions as a key step in the total synthesis of natural products and highlights on natural sources, structures, and biological activities of the promising natural products for the first time elegantly.
天然产物及其类似物在药物发现和开发过程中发挥了关键作用。在实验室中，次生代谢产物的全合成对于确定天然来源分子的假设复杂结构非常有用。本综述探讨了以Norrish I型和II型反应为关键步骤的天然产物全合成。Norrish反应是有机合成化学中羰基化合物重要的光诱导转化反应，与许多工业和生物学相关过程以及大气中羰基化合物的处理有关。本综述试图聚焦于Norrish I型和II型光化学反应在天然产物全合成中的卓越应用，并首次优雅地突出了有前景的天然产物的天然来源、结构和生物活性。
