依那普利治疗原发性雷诺现象的主观和客观评估
Subjective and objective assessment of enalapril in primary Raynaud's phenomenon.
作者信息
Challenor V F, Waller D G, Hayward R A, Griffin M J, Roath O S
机构信息
Institute of Sound and Vibration Research, Southampton General Hospital.
出版信息
Br J Clin Pharmacol. 1991 Apr;31(4):477-80. doi: 10.1111/j.1365-2125.1991.tb05565.x.
Abstract
- The efficacy and acceptability of enalapril were assessed in a double-blind, randomised, placebo controlled cross-over study in 21 patients with primary Raynaud's phenomenon. 2. Skin temperature was assessed by thermocouples in response to a 15 degrees C cold water challenge as an index of digital blood flow. 3. Following enalapril there were no significant changes in the number and severity of Raynaud's attacks, and no subjective benefit from treatment as measured by visual analogue scales, 5 point rating scales, and skin temperature response to cold challenge when compared with placebo. 4. Enalapril in a dose of 20 mg daily is ineffective in the management of primary Raynaud's phenomenon.
摘要
- 在一项针对21例原发性雷诺现象患者的双盲、随机、安慰剂对照交叉研究中，评估了依那普利的疗效和可接受性。2. 通过热电偶测量皮肤温度，以应对15摄氏度冷水刺激，作为指端血流的指标。3. 服用依那普利后，雷诺发作的次数和严重程度没有显著变化，与安慰剂相比，通过视觉模拟量表、5分制量表以及冷刺激后的皮肤温度反应来衡量，治疗没有主观益处。4. 每日剂量为20毫克的依那普利对原发性雷诺现象的治疗无效。
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