Frankfurt Institute for Molecular Life Sciences and Institute of Biochemistry II, Goethe University, Frankfurt, Germany.
Nat Struct Mol Biol. 2010 Jun;17(6):666-72. doi: 10.1038/nsmb.1842. Epub 2010 May 23.
Post-translational modifications of proteins and the domains that recognize these modifications have central roles in creating a highly dynamic relay system that reads and responds to alterations in the cellular microenvironment. Here we review the common principles of post-translational modifications and their importance in signal integration underlying epidermal growth factor receptor signaling and endocytosis, DNA-damage responses and immunity.
蛋白质的翻译后修饰以及识别这些修饰的结构域在构建一个高度动态的中继系统中起着核心作用，该系统可读取和响应细胞微环境的变化。在这里，我们回顾了翻译后修饰的常见原理及其在表皮生长因子受体信号转导和内吞作用、DNA 损伤反应和免疫的信号整合中的重要性。
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