Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Surg Today. 2010 Jun;40(6):543-8. doi: 10.1007/s00595-008-4086-y. Epub 2010 May 23.
Interleukin-8 (IL-8) is a neutrophil chemotactic factor, which is associated with some inflammatory diseases and various types of surgical stress. The aim of this study was to investigate whether the early postoperative serum IL-8 level may potentially be a new indicator of a surgical stress in patients undergoing a hepatic resection.
The serum IL-8 levels were measured in 37 patients who underwent a hepatectomy. The serum IL-8 levels were serially measured using an enzyme-linked immunosorbent assay both before and after a hepatic resection. In addition, the correlation between the postoperative IL-8 value and several clinical variables were examined.
The mean level of IL-8 significantly increased immediately after the operation (P < 0.01 vs before the operation) and decreased on the first postoperative day (POD 1, P < 0.05 vs after the operation). The early postoperative IL-8 levels positively correlated with the length of the procedure (r = 0.383; P < 0.05), the estimated blood loss (r = 0.483; P < 0.01) and the serum bilirubin level on POD 1 (r = 0.390; P < 0.05), and inversely correlated with the white blood cell counts (r = -0.388; P < 0.05) and lymphocyte counts on POD 1 (r = -0.424; P < 0.05). In a comparison of the postoperative IL-8 levels with the surgical factors, there was a significant difference in the extension of the resection (P < 0.05) and in blood transfusion. The patients with a fever of more than 38 degrees C showed higher levels of IL-8 immediately after the operation than those without fever (P < 0.01).
The early postoperative serum IL-8 level was found to correlate with the degree of the severity of surgery in patients undergoing a hepatic resection, and it is also considered to be a new indicator of surgical stress and liver injury.
白细胞介素-8（IL-8）是一种中性粒细胞趋化因子，与某些炎症性疾病和各种类型的外科应激有关。本研究旨在探讨肝切除术后早期血清 IL-8 水平是否可能成为患者手术应激的新指标。
对 37 例行肝切除术的患者进行了血清 IL-8 水平的测量。使用酶联免疫吸附试验连续测量肝切除术前和术后的血清 IL-8 水平。此外，还检查了术后 IL-8 值与几个临床变量之间的相关性。
IL-8 的平均水平在手术后立即显著升高（P < 0.01 与术前相比），并在术后第 1 天（POD1，P < 0.05 与手术后相比）下降。术后早期 IL-8 水平与手术时间（r = 0.383；P < 0.05）、估计出血量（r = 0.483；P < 0.01）和 POD1 时的血清胆红素水平（r = 0.390；P < 0.05）呈正相关，与白细胞计数（r = -0.388；P < 0.05）和 POD1 时的淋巴细胞计数（r = -0.424；P < 0.05）呈负相关。在将术后 IL-8 水平与手术因素进行比较时，在切除范围的扩大（P < 0.05）和输血方面存在显著差异。发热超过 38 度的患者术后即刻的 IL-8 水平高于无发热的患者（P < 0.01）。
肝切除术后早期血清 IL-8 水平与手术严重程度相关，被认为是手术应激和肝损伤的新指标。
