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本文引用的文献

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The role of serum interleukin-8 in hepatic resections.血清白细胞介素-8 在肝切除术中的作用。
Surg Today. 2010 Jun;40(6):543-8. doi: 10.1007/s00595-008-4086-y. Epub 2010 May 23.
2
Prognostic utility of postoperative C-reactive protein for posthepatectomy liver failure.术后C反应蛋白对肝切除术后肝衰竭的预后评估价值
Arch Surg. 2008 Mar;143(3):247-53; discussion 253. doi: 10.1001/archsurg.2007.75.
3
Ischemia-reperfusion of small liver remnant promotes liver tumor growth and metastases--activation of cell invasion and migration pathways.小肝残余缺血再灌注促进肝肿瘤生长和转移——细胞侵袭和迁移途径的激活
Liver Transpl. 2007 Dec;13(12):1669-77. doi: 10.1002/lt.21193.
4
Preoperative high-dose steroid administration attenuates the surgical stress response following liver resection: results of a prospective randomized study.术前大剂量使用类固醇可减轻肝切除术后的手术应激反应:一项前瞻性随机研究的结果
J Hepatobiliary Pancreat Surg. 2007;14(5):484-92. doi: 10.1007/s00534-006-1200-7. Epub 2007 Sep 28.
5
Tumour necrosis factor-alpha (TNFalpha) and interleukin-10 are crucial mediators in post-operative systemic inflammatory response and determine the occurrence of complications after major abdominal surgery.肿瘤坏死因子-α(TNFα)和白细胞介素-10是术后全身炎症反应的关键介质,并决定了腹部大手术后并发症的发生。
Cytokine. 2007 Jan;37(1):55-61. doi: 10.1016/j.cyto.2007.02.023. Epub 2007 Apr 10.
6
Circulating cytokines, chemokines, and stress hormones are increased in patients with organ dysfunction following liver resection.肝切除术后出现器官功能障碍的患者,其循环细胞因子、趋化因子和应激激素水平会升高。
J Surg Res. 2006 Jun 15;133(2):102-12. doi: 10.1016/j.jss.2005.10.025. Epub 2006 Jan 4.
7
Inhibition of classical complement activation attenuates liver ischaemia and reperfusion injury in a rat model.在大鼠模型中,抑制经典补体激活可减轻肝脏缺血再灌注损伤。
Clin Exp Immunol. 2006 Jan;143(1):15-23. doi: 10.1111/j.1365-2249.2005.02958.x.
8
Beneficial effects of ischemic preconditioning in patients undergoing hepatectomy: the role of neutrophils.缺血预处理对肝切除患者的有益作用:中性粒细胞的作用。
Arch Surg. 2005 Feb;140(2):129-36. doi: 10.1001/archsurg.140.2.129.
9
Effects of hepatovenous back flow on ischemic- reperfusion injuries in liver resections with the pringle maneuver.肝静脉回流对采用普林格尔手法进行肝切除术中缺血再灌注损伤的影响。
J Am Coll Surg. 2003 Dec;197(6):949-54. doi: 10.1016/j.jamcollsurg.2003.07.009.
10
Enhanced inflammatory cytokine production at ischemia/reperfusion in human liver resection.人类肝切除术中缺血/再灌注时炎性细胞因子产生增加。
Hepatogastroenterology. 2002 Jul-Aug;49(46):1077-82.

肝切除术中手术应激的免疫学评估

Immunological Evaluation of Surgical Stress in Liver Resections.

作者信息

Munteanu Alexandru, Samasca Gabriel, Lupan Iulia, Iancu Cornel

机构信息

Department of Surgery, "Octavian Fodor" Regional Institute of Gastroenterology and Hepatology, Cluj-Napoca, Romania.

Department of Immunology, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.

出版信息

Maedica (Bucur). 2017 Dec;12(4):289-292.

PMID:29610593
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5879590/
Abstract

Surgery has its origins in caring for patients suffering from injury or infection. In the last decade, a huge amount of published data has been describing a wide range of conditions resulting from trauma or infection, from minor, local reactions to a surgical operation and leading to a systemic stress response, systemic inflammatory response and finally to multiple organ failure. Our aim was to highlight the main immunological aspects of liver resections. There are many types of liver resections, ranging from small, isolated resections for benign diseases (e.g., small cysts or angyoma) to segmentectomies, bi- or trisegmentectomies to hepatectomies in the end. Patients undergoing such resections are subjected to a large amount of surgical stress and in some cases, postoperative complications ranging from light to severe. The main links between immunology and liver resections is surgical stress that can be evaluated through various immunological methods, which will be presented in this article.

摘要

外科手术起源于对受伤或感染患者的护理。在过去十年中,大量已发表的数据描述了由创伤或感染导致的广泛病症,从外科手术引起的轻微局部反应,到全身应激反应、全身炎症反应,最终发展为多器官功能衰竭。我们的目的是突出肝切除术的主要免疫学方面。肝切除术有多种类型,从针对良性疾病的小范围孤立性切除(如小囊肿或血管瘤),到肝段切除术、双段或三段肝段切除术,直至最终的肝切除术。接受此类切除术的患者会承受大量手术应激,在某些情况下还会出现从轻度到重度的术后并发症。免疫学与肝切除术之间的主要联系在于手术应激,可通过各种免疫学方法对其进行评估,本文将对此进行阐述。