Department of Radiology, Medical School, Celal Bayar University, Manisa, Turkey.
Eur J Pediatr. 2010 Nov;169(11):1345-52. doi: 10.1007/s00431-010-1227-2. Epub 2010 May 25.
(1) to evaluate the frequency of asymptomatic fatty liver disease (FLD) using both Doppler and B-mode ultrasound (US) in overweight and obese adolescents; (2) to compare metabolic findings of fatty liver (FL) assessed by two methods; and (3) to evaluate metabolic predictors of FL shown by these methods. Fifty-nine overweight and obese adolescents aged between 9.0 and 17.0 years and 41 non-obese healthy adolescents were included in this study. B-mode and right hepatic vein Doppler ultrasonography (US) were performed and anthropometric indices, lipid profiles, and adiponectin levels were evaluated in all adolescents. HDL-C levels were significantly lower in patients with FL detected by Doppler US compared to patients without FL (p < 0.05). HDL-C levels were inversely correlated with presence of FL assessed by two methods (r = -0.285, p = 0.004; r = -0.328, p = 0.001, respectively) and adiponectin levels were correlated with presence of FL only detected by B-mode US (r = -0.263, p = 0.008). Adiponectin levels were significantly lower in patients with FL than those without FL assessed by B-Mode US (p = 0.049). Multiple regression analysis revealed that HDL-C levels was the most important predictor of FL assessed by Doppler US (p = 0.027), while body mass index was the determinant of FL assessed by two methods (p < 0.001) in asymptomatic overweight and obese adolescents. It was found that FLD, identified by both B-mode and Doppler US, is seen frequently in asymptomatic overweight and obese adolescents. Elevated BMI is associated with increased risk of FL assessed by two ultrasonographic methods. When using Doppler US, low HDL-C levels can be used as a good predictor for presence of FLD in overweight and obese adolescents.
（1）评估超重和肥胖青少年使用多普勒和 B 型超声（US）的无症状性脂肪肝疾病（FLD）的频率；（2）比较两种方法评估的脂肪肝（FL）的代谢发现；（3）评估这些方法显示的 FL 的代谢预测因子。本研究纳入 59 名年龄在 9.0 至 17.0 岁之间的超重和肥胖青少年和 41 名非肥胖健康青少年。对所有青少年进行 B 型和右肝静脉多普勒超声（US）检查，并评估其人体测量指标、血脂谱和脂联素水平。与未检测到多普勒 US 的 FL 患者相比，HDL-C 水平在多普勒 US 检测到的 FL 患者中显著降低（p<0.05）。HDL-C 水平与两种方法评估的 FL 存在呈负相关（r=-0.285，p=0.004；r=-0.328，p=0.001），脂联素水平仅与 B 型 US 检测到的 FL 存在相关（r=-0.263，p=0.008）。与 B 型 US 未检测到 FL 的患者相比，脂联素水平在 FL 患者中显著降低（p=0.049）。多元回归分析显示，HDL-C 水平是多普勒 US 评估 FL 的最重要预测因子（p=0.027），而体质指数是两种方法评估 FL 的决定因素（p<0.001）在无症状超重和肥胖青少年中。结果发现，通过 B 型和多普勒 US 检测到的 FLD 在无症状超重和肥胖青少年中很常见。较高的 BMI 与两种超声方法评估的 FL 风险增加相关。当使用多普勒 US 时，低 HDL-C 水平可作为超重和肥胖青少年中 FLD 存在的良好预测因子。
