Nicolle L E, Degelau J, Alessi P, Cullison J, Meyers B
University of Manitoba, Winnipeg, Canada.
Chemotherapy. 1991;37 Suppl 1:49-54. doi: 10.1159/000238906.
The efficacy and safety of ofloxacin for the treatment of pneumonia, urinary infection and skin infections in the institutionalized elderly is being studied in a multicenter North American trial. The two study arms include an open, randomized, comparison of intravenous or oral ofloxacin with standard therapy in subjects requiring admission to acute care institutions, and an open study of oral ofloxacin in residents of chronic care facilities. To date 58 subjects have been enrolled with a mean age of 84 +/- 8 years. The preliminary observations from this ongoing multicenter study suggest that ofloxacin will be a safe and effective option for antimicrobial therapy in the treatment of these common infections in the institutionalized elderly.
一项北美多中心试验正在研究氧氟沙星治疗机构养老老年人肺炎、泌尿系统感染和皮肤感染的疗效及安全性。两个研究组包括：一项针对需要入住急性护理机构的受试者进行的开放、随机试验，比较静脉或口服氧氟沙星与标准疗法；以及一项针对长期护理机构居民进行的口服氧氟沙星开放研究。迄今为止，已招募58名受试者，平均年龄为84±8岁。这项正在进行的多中心研究的初步观察结果表明，氧氟沙星将是治疗机构养老老年人这些常见感染的一种安全有效的抗菌治疗选择。
