Institute for Ubiquitous Information Technology and Applications (UBITA) & Center for Biotechnology Research in UBITA (CBRU), Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Korea.
Department of Bioscience and Biotechnology, Microbial Carbohydrate Resource Bank (MBRC) & Center for Biotechnology Research in UBITA (CBRU), Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Korea.
Molecules. 2018 Jan 4;23(1):107. doi: 10.3390/molecules23010107.
Polydiacetylene (PDA) has attracted interest for use as a sensing platform in biomedical, environmental, and chemical engineering applications owing to its capacity for colorimetric and fluorescent transition in response to external stimuli. Many researchers have attempted to develop a tailor-made PDA sensor via conjugation of chemical or biological substances to PDA. Here, we review smart bio-conjugates of PDA with various biomolecules such as carbohydrates, lipids, nucleic acids, and proteins. In addition, materialization and signal amplification strategies to improve handling and sensitivity are described.
聚二乙炔（PDA）因其对外界刺激的比色和荧光转变能力，在生物医学、环境和化学工程应用中作为传感平台引起了关注。许多研究人员试图通过将化学或生物物质与 PDA 结合来开发定制的 PDA 传感器。在这里，我们回顾了 PDA 与各种生物分子（如碳水化合物、脂质、核酸和蛋白质）的智能生物缀合物。此外，还描述了实现和信号放大策略，以提高处理和灵敏度。
