环境致癌物风险评估中的生物标志物。
Biologic markers in risk assessment for environmental carcinogens.
作者信息
Perera F, Mayer J, Santella R M, Brenner D, Jeffrey A, Latriano L, Smith S, Warburton D, Young T L, Tsai W Y
机构信息
Columbia University School of Public Health, New York, NY 10032.
出版信息
Environ Health Perspect. 1991 Jan;90:247-54. doi: 10.1289/ehp.90-1519502.
Abstract
The potential of biologic markers to provide more timely and precise risk assessments for environmental carcinogens is viewed against the current state-of-the-art in biological monitoring/molecular epidemiology. Biologic markers such as carcinogen-DNA adducts and oncogene activation are currently considered valid qualitative indicators of potential risk, but for most chemical exposures research is needed to establish their validity as quantitative predictors of cancer risk. Biologic markers have, however, already provided valuable insights into the magnitude of interindividual variation in response to carcinogenic exposures, with major implications for risk assessment.
摘要
对照生物监测/分子流行病学的当前技术水平，评估生物标志物为环境致癌物提供更及时、精确风险评估的潜力。诸如致癌物-DNA加合物和癌基因激活等生物标志物目前被视为潜在风险的有效定性指标，但对于大多数化学物质暴露而言，仍需开展研究以确定其作为癌症风险定量预测指标的有效性。然而，生物标志物已为了解个体对致癌物质暴露反应的个体间差异程度提供了宝贵见解，这对风险评估具有重要意义。
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