Paigen B, Ward E, Reilly A, Houten L, Gurtoo H L, Minowada J, Steenland K, Havens M B, Sartori P
Cancer Res. 1981 Jul;41(7):2757-61.
A seasonal variation was observed when aryl hydrocarbon hydroxylase (AHH) activity was measured in the cultured lymphocytes of 977 donors over a period of 2 1/2 years. The variation was strongest in AHH activity induced by 3-methylcholanthrene and was less apparent for AHH activity in lymphocytes grown without any inducer. The period of the seasonal variation is 1 year, and maximal induced AHH activity occurs during late summer and early fall with minimal activity 6 months later. Based on the average of all individuals tested during the highest and lowest weeks, induced AHH activity can be as much as 10-fold higher during the peak season. It is not possible to tell from these experiments whether the seasonal variation is tissue specific, occurring only in lymphocytes, or characteristic of microsomal oxidases in other tissues as well.
在2年半的时间里，对977名捐赠者的培养淋巴细胞进行芳烃羟化酶（AHH）活性检测时，观察到了季节性变化。这种变化在由3-甲基胆蒽诱导的AHH活性中最为明显，而在没有任何诱导剂的情况下生长的淋巴细胞中的AHH活性变化则不太明显。季节性变化的周期为1年，诱导的AHH活性最大值出现在夏末和初秋，6个月后活性最低。根据在最高和最低周测试的所有个体的平均值，在旺季诱导的AHH活性可能比平时高10倍。从这些实验中无法判断季节性变化是否具有组织特异性，仅发生在淋巴细胞中，还是其他组织中的微粒体氧化酶也具有这种特征。
