半月板、钙化和骨关节炎：病理团队。
The meniscus, calcification and osteoarthritis: a pathologic team.
出版信息
Arthritis Res Ther. 2010;12(3):116. doi: 10.1186/ar2993. Epub 2010 May 20.
Abstract
Articular calcification correlates with osteoarthritis (OA) severity but its exact role in the disease process is unclear. In examining OA meniscal cell function, Sun and colleagues have shown recently that meniscal cells from end-stage OA subjects can generate calcium crystals and that genes involved in calcification are upregulated in OA meniscal cells. Also, this in vitro calcium deposition by OA menisci is inhibited by phosphocitrate. This study should catalyse further work examining the pathological contribution or otherwise of calcium crystals in OA. This would significantly aid the development of potential disease modifying agents in OA, which are currently unavailable.
摘要
关节钙化与骨关节炎（OA）的严重程度相关，但它在疾病过程中的具体作用尚不清楚。在研究 OA 半月板细胞功能时，Sun 及其同事最近表明，终末期 OA 患者的半月板细胞可以产生钙晶体，OA 半月板细胞中的钙化相关基因上调。此外，OA 半月板的体外钙沉积被膦羧酸所抑制。这项研究应进一步促进检查 OA 中钙晶体的病理贡献或其他方面的工作。这将极大地帮助开发目前尚无的 OA 潜在疾病修饰剂。
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