Kornhuber J, Kornhuber M E, Hartmann G M, Kornhuber A W
Department of Neurology, University of Ulm, Steinhövelstr.9, 7900 Ulm, F.R.G.
Neurochem Int. 1988;12(1):25-31. doi: 10.1016/0197-0186(88)90144-1.
The concentration of 19 amino acids and ethanolamine in two independent groups (n = 36, n = 19) of normal human cerebrospinal fluid (CSF) samples were measured by high performance liquid chromatography. Age, sex, time of lumbar puncture, position during lumbar puncture, protein and glucose content of the CSF were monitored and the influence of these parameters on CSF amino acid levels was determined. Hypotheses formulated after observing measurements from the first group of CSF samples were tested against the second group of CSF samples using conservative statistics. The main finding was a positive correlation between CSF glucose and CSF glutamate levels.
通过高效液相色谱法测量了两组独立的正常人脑脊液（CSF）样本（n = 36，n = 19）中19种氨基酸和乙醇胺的浓度。监测了年龄、性别、腰椎穿刺时间、腰椎穿刺时的体位、CSF的蛋白质和葡萄糖含量，并确定了这些参数对CSF氨基酸水平的影响。根据第一组CSF样本的测量结果提出的假设，使用保守统计学方法在第二组CSF样本中进行了检验。主要发现是CSF葡萄糖与CSF谷氨酸水平之间呈正相关。
