Centre for Biophotonics, University of Strathclyde, Glasgow G4 0NR, UK.
Exp Parasitol. 2010 Nov;126(3):310-7. doi: 10.1016/j.exppara.2010.05.014. Epub 2010 May 23.
An understanding of host-parasite interplay is essential for the development of therapeutics and vaccines. Immunoparasitologists have learned a great deal from 'conventional'in vitro and in vivo approaches, but recent developments in imaging technologies have provided us (immunologists and parasitologists) with the ability to ask new and exciting questions about the dynamic nature of the parasite-immune system interface. These studies are providing us with new insights into the mechanisms involved in the initiation of a Leishmania infection and the consequent induction and regulation of the immune response. Here, we review some of the recent developments and discuss how these observations can be further developed to understand the immunology of cutaneous Leishmania infection in vivo.
宿主-寄生虫相互作用的理解对于治疗方法和疫苗的开发至关重要。免疫寄生虫学家从“传统”的体外和体内方法中学到了很多东西，但成像技术的最新发展使我们（免疫学家和寄生虫学家）能够提出关于寄生虫-免疫系统界面动态性质的新的令人兴奋的问题。这些研究为我们提供了对引发利什曼原虫感染以及随后诱导和调节免疫反应的机制的新见解。在这里，我们回顾了一些最新的发展，并讨论了如何进一步发展这些观察结果，以了解体内皮肤利什曼原虫感染的免疫学。
