Xu Bing, Lin Huan-bing, Zhou Heng, Xu Jiang-ping
Department of Pharmacology, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
Nan Fang Yi Ke Da Xue Xue Bao. 2010 May;30(5):1041-3.
To evaluate the protective effect of polydatin on a PC12 cell model of oxygen and glucose deprivation (OGD).
A pheochromocytoma cell injury model was induced by OGD to simulate the cerebral ischemic changes. The protective effects of polydatin were investigated in this model.
Polydatin treatment significantly enhanced the cell viability and reduced the levels of lactate dehydrogenase, nitric oxide and the malondialdehyde of the pheochromocytoma cells as compared with the OGD group. Polydatin also increased the activity of superoxide dismutase in the cells.
Polydatin offers protective effect against OGD-induced injury in pheochromocytoma cells.
评估白藜芦醇苷对氧糖剥夺（OGD）的PC12细胞模型的保护作用。
通过OGD诱导嗜铬细胞瘤细胞损伤模型以模拟脑缺血变化。在此模型中研究白藜芦醇苷的保护作用。
与OGD组相比，白藜芦醇苷处理显著提高了嗜铬细胞瘤细胞的活力，并降低了乳酸脱氢酶、一氧化氮和丙二醛的水平。白藜芦醇苷还增加了细胞中超氧化物歧化酶的活性。
白藜芦醇苷对OGD诱导的嗜铬细胞瘤细胞损伤具有保护作用。
