Department of Diving Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai 200433, China.
Phytomedicine. 2012 Jun 15;19(8-9):677-81. doi: 10.1016/j.phymed.2012.03.002. Epub 2012 Apr 4.
Polydatin is one of the most common encountered stilbenes of nature and a key component of the Chinese herb Polygonum cuspidatum. This study is to investigate the effects of polydatin on learning and memory impairments induced by chronic cerebral hypoperfusion in rats, as well as the potential mechanism. Both common carotid arteries and both vertebral arteries occlusion (four-vessel occlusion, 4-VO) induced severe cognitive deficits tested by water maze task, along with oxidative stress in hippocampus. Oral administration of polydatin for 30 days markedly attenuated cognitive deficits compared with the control (p < 0.05). Biochemical determination revealed that polydatin decreased the production of malondialdehyde (MDA) and significantly increased the activities of superoxide dismutase (SOD) and catalase (CAT). Additionally, polydatin effectively alleviated the injuries of cultured neurons induced by oxygen-glucose deprivation (OGD). These results suggest that polydatin exhibit therapeutic potential for vascular dementia, which is most likely related, at least in part, to its anti-oxidant activity and the direct protection of neurons.
虎杖苷是自然界中最常见的白藜芦醇之一，也是中药虎杖的主要成分。本研究旨在探讨虎杖苷对慢性大脑低灌注诱导的大鼠学习记忆障碍的作用及可能机制。双侧颈总动脉和双侧椎动脉闭塞（四血管闭塞，4-VO）导致水迷宫任务测试认知功能严重受损，同时伴有海马氧化应激。与对照组相比，虎杖苷口服 30 天可显著改善认知障碍（p<0.05）。生化测定显示，虎杖苷降低了丙二醛（MDA）的产生，显著增加了超氧化物歧化酶（SOD）和过氧化氢酶（CAT）的活性。此外，虎杖苷还能有效减轻氧葡萄糖剥夺（OGD）诱导的培养神经元损伤。这些结果表明，虎杖苷对血管性痴呆具有治疗潜力，这与其抗氧化活性和对神经元的直接保护作用有关。
