Department of Pathology, Bács-Kiskun County Teaching Hospital, Kecskemét, Nyiri ut, Hungary.
J Clin Pathol. 2010 Jul;63(7):575-8. doi: 10.1136/jcp.2010.075846. Epub 2010 May 24.
To assess venous invasion (VI) and its relation to distant metastases in colorectal cancer (CRC).
Primary untreated CRC cases were assessed for VI. All tumour blocks were stained with H&E and orcein. The presence of VI and nodal status were then correlated with the presence of synchronous or metachronous distant metastases.
VI was detected more frequently with the orcein stain (18% versus 71%). Eleven tumours (nine node-positive tumours, all VI positive) were associated with synchronous distant metastasis. During a median follow-up of 17 months nine further cases were diagnosed with distant metastasis (six node-positive tumours, all VI positive). The specificity and sensitivity of the presence of nodal metastasis for predicting distant metastasis were 0.56 and 0.75, respectively. The same values for orcein-detected VI were 0.39 and 1, respectively.
Elastic stains such as the orcein stain enable the detection of clinically relevant VI with greater frequency than conventionally stained histological slides. If nodal involvement is an indication for systemic chemotherapy, the data presented here suggest that VI detected by the orcein stain should also be an indication for systemic chemotherapy.
评估结直肠癌（CRC）中的静脉侵犯（VI）及其与远处转移的关系。
对未经治疗的原发性 CRC 病例进行 VI 评估。所有肿瘤块均用 H&E 和地衣红染色。然后将 VI 的存在与同步或异时性远处转移的存在相关联。
地衣红染色检测到 VI 的频率更高（18%比 71%）。11 个肿瘤（9 个淋巴结阳性肿瘤，均为 VI 阳性）与同步远处转移相关。在中位数为 17 个月的随访期间，又有 9 例被诊断为远处转移（6 个淋巴结阳性肿瘤，均为 VI 阳性）。淋巴结转移存在预测远处转移的特异性和敏感性分别为 0.56 和 0.75。地衣红检测到的 VI 的相同值分别为 0.39 和 1。
与传统染色的组织学切片相比，弹性染色（如地衣红染色）能够更频繁地检测到具有临床相关性的 VI。如果淋巴结受累是全身化疗的指征，那么这里提供的数据表明，地衣红染色检测到的 VI 也应该是全身化疗的指征。
