骨重建的细胞和分子机制。
Cellular and molecular mechanisms of bone remodeling.
机构信息
Faculty of Health Sciences, The University of Queensland Centre for Clinical Research, Royal Brisbane Hospital, Herston 4029, Australia.
出版信息
J Biol Chem. 2010 Aug 13;285(33):25103-8. doi: 10.1074/jbc.R109.041087. Epub 2010 May 25.
Abstract
Physiological bone remodeling is a highly coordinated process responsible for bone resorption and formation and is necessary to repair damaged bone and to maintain mineral homeostasis. In addition to the traditional bone cells (osteoclasts, osteoblasts, and osteocytes) that are necessary for bone remodeling, several immune cells have also been implicated in bone disease. This minireview discusses physiological bone remodeling, outlining the traditional bone biology dogma in light of emerging osteoimmunology data. Specifically discussed in detail are the cellular and molecular mechanisms of bone remodeling, including events that orchestrate the five sequential phases of bone remodeling: activation, resorption, reversal, formation, and termination.
摘要
生理骨重塑是一个高度协调的过程，负责骨吸收和形成，对于修复受损的骨骼和维持矿物质的体内平衡是必需的。除了传统的骨细胞（破骨细胞、成骨细胞和成骨细胞）对骨重塑是必需的之外，几种免疫细胞也与骨疾病有关。这篇小综述讨论了生理骨重塑，根据新兴的骨免疫学数据，概述了传统的骨生物学教条。本文详细讨论了骨重塑的细胞和分子机制，包括协调骨重塑的五个连续阶段（激活、吸收、逆转、形成和终止）的事件。
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本文引用的文献
1
TGF-beta1-induced migration of bone mesenchymal stem cells couples bone resorption with formation.
Nat Med. 2009 Jul;15(7):757-65. doi: 10.1038/nm.1979. Epub 2009 Jul 5.
2
Identification of cell cycle-arrested quiescent osteoclast precursors in vivo.
J Cell Biol. 2009 Feb 23;184(4):541-54. doi: 10.1083/jcb.200806139.
3
A physical mechanism for coupling bone resorption and formation in adult human bone.
Am J Pathol. 2009 Jan;174(1):239-47. doi: 10.2353/ajpath.2009.080627. Epub 2008 Dec 18.
4
Differentiation and heterogeneity in the mononuclear phagocyte system.
Mucosal Immunol. 2008 Nov;1(6):432-41. doi: 10.1038/mi.2008.36. Epub 2008 Aug 27.
5
Regulation of bone formation by osteoclasts involves Wnt/BMP signaling and the chemokine sphingosine-1-phosphate.
Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20764-9. doi: 10.1073/pnas.0805133106. Epub 2008 Dec 15.
6
Osteal macrophages: a new twist on coupling during bone dynamics.
Bone. 2008 Dec;43(6):976-82. doi: 10.1016/j.bone.2008.08.128. Epub 2008 Sep 16.
7
Metalloproteinase expression in monocytes and macrophages and its relationship to atherosclerotic plaque instability.
Arterioscler Thromb Vasc Biol. 2008 Dec;28(12):2108-14. doi: 10.1161/ATVBAHA.108.173898. Epub 2008 Sep 4.
8
Transcriptional control of skeletogenesis.
Annu Rev Genomics Hum Genet. 2008;9:183-96. doi: 10.1146/annurev.genom.9.081307.164437.
9
Osteitis fibrosa is mediated by Platelet-Derived Growth Factor-A via a phosphoinositide 3-kinase-dependent signaling pathway in a rat model for chronic hyperparathyroidism.
Endocrinology. 2008 Nov;149(11):5735-46. doi: 10.1210/en.2008-0134. Epub 2008 Jul 17.
10
Osteal tissue macrophages are intercalated throughout human and mouse bone lining tissues and regulate osteoblast function in vitro and in vivo.
J Immunol. 2008 Jul 15;181(2):1232-44. doi: 10.4049/jimmunol.181.2.1232.
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