Institute of Endocrinology and Diabetology at Fudan University, Department of Endocrinology and Metabolism, Huashan Hospital affiliated with Fudan University, no. 12 Wulumuqi Middle Road, Shanghai 200040, China.
J Clin Endocrinol Metab. 2010 Aug;95(8):3926-32. doi: 10.1210/jc.2009-2194. Epub 2010 May 25.
Recent study showed high chemokine CXC ligand 5 (CXCL5) is thought to be associated with insulin resistance in humans. However, evidence from large-scale populations about the relationship between serum CXCL5 level and metabolic phenotypes is scarce. Here we sought to evaluate serum CXCL5 distribution and its association with metabolic phenotypes among middle-aged and older Chinese.
We evaluated serum CXCL5 in a cross-sectional sample of 3225 Chinese aged from 50 to 88 yr in a Shanghai downtown district by ELISA. Glucose, insulin, lipid profile, inflammatory marker, and adipokine were also measured.
The crude mean of serum CXCL5 concentrations were 1493.31 pg/ml for men and 2059.42 pg/ml for women (P<0.001), respectively. After multiple adjustment, the odds ratios were substantially higher for hypercholesterolemia (odds ratio 3.26, 95% confidence interval 2.36-4.51) in the highest CXCL5 quartile compared with those in the lowest quartile. These associations remained significant after further adjustment for body mass index, body fat, inflammatory marker, and adipokine. However, serum resistin CXCL5 was not associated with body mass index, percent body fat, fasting glucose, insulin levels, and homeostasis model assessment index-insulin resistance (r=0.01, 0.01, 0.01, 0.04, and 0.03, respectively; all P>0.05).
Elevated circulating CXCL5 concentrations were associated with higher risk of hypercholesterolemia in middle-aged and elderly Chinese independent of obesity, inflammation, adipokines, and other risk factors but not insulin resistance.
最近的研究表明，趋化因子 CXC 配体 5（CXCL5）水平升高与人类的胰岛素抵抗有关。然而，关于血清 CXCL5 水平与代谢表型之间的关系，在大规模人群中证据仍然较少。本研究旨在评估中国中老年人群血清 CXCL5 分布及其与代谢表型的关系。
我们通过 ELISA 检测了上海市中心地区年龄在 50-88 岁的 3225 名中国人的血清 CXCL5。还测量了血糖、胰岛素、血脂谱、炎症标志物和脂肪因子。
男性和女性的血清 CXCL5 浓度分别为 1493.31pg/ml 和 2059.42pg/ml（P<0.001）。经过多重调整后，CXCL5 浓度最高四分位数组发生高胆固醇血症的比值比（OR）明显高于最低四分位数组（OR 3.26，95%可信区间 2.36-4.51）。在进一步调整体重指数、体脂、炎症标志物和脂肪因子后，这些相关性仍然显著。然而，血清抵抗素与体重指数、体脂百分比、空腹血糖、胰岛素水平和稳态模型评估-胰岛素抵抗指数（r=0.01、0.01、0.01、0.04 和 0.03，均 P>0.05）无关。
在中年和老年中国人中，循环 CXCL5 浓度升高与高胆固醇血症风险增加相关，这种相关性独立于肥胖、炎症、脂肪因子和其他危险因素，但与胰岛素抵抗无关。
