Department of Endocrinology, Fudan University, Shanghai, China.
Cardiovasc Diabetol. 2013 Jan 23;12:22. doi: 10.1186/1475-2840-12-22.
To investigate the association of serum osteocalcin with carotid atherosclerosis in patients with type 2 diabetes.
We performed a cross-sectional community-based study in metropolitan area. Serum total osteocalcin was measured by radioimmunoassay in 382 men and 435 postmenopausal women. The carotid artery intima-media thickness (IMT) and carotid plaques (PLQ) were measured by B-mode ultrasound.
The crude mean of serum osteocalcin concentrations were 4.52±2.43 ng/ml for men and 5.75±2.92 ng/ml for postmenopausal women (P <0.001), respectively. Osteocalcin levels were associated inversely with age, fasting serum insulin, HOMA-IR, ALT, triglycerides, total cholesterol, LDL- cholesterol, CRP (all P<0.001) and positively with adiponectin and HOMA-B (all P<0.05). After multiple adjustment, the odds ratios (ORs) were substantially higher risk for carotid plaques (OR 1.77 for 1 SD decrease in osteocalcin, 95% CI 1.23-2.76, p=0.005). These associations remained significant after further adjustment for potential confounder.
Serum osteocalcin levels is an independent risk factor for carotid atherosclerosis in patients with type 2 diabetes.
探讨 2 型糖尿病患者血清骨钙素与颈动脉粥样硬化的关系。
我们在大都市区进行了一项横断面社区研究。采用放射免疫法测定 382 名男性和 435 名绝经后女性的血清总骨钙素。通过 B 型超声测量颈动脉内膜中层厚度（IMT）和颈动脉斑块（PLQ）。
男性和绝经后女性的血清骨钙素浓度的粗均值分别为 4.52±2.43ng/ml 和 5.75±2.92ng/ml（P<0.001）。骨钙素水平与年龄、空腹血清胰岛素、HOMA-IR、ALT、甘油三酯、总胆固醇、LDL-胆固醇、CRP 呈负相关（均 P<0.001），与脂联素和 HOMA-B 呈正相关（均 P<0.05）。经过多因素调整后，颈动脉斑块的风险比（OR）显著增加（骨钙素每降低 1SD，OR 为 1.77，95%CI 1.23-2.76，p=0.005）。进一步调整潜在混杂因素后，这些关联仍然显著。
血清骨钙素水平是 2 型糖尿病患者颈动脉粥样硬化的独立危险因素。
