Institute of Endocrinology and Diabetology, Huashan hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Cardiovasc Diabetol. 2012 Jan 31;11:11. doi: 10.1186/1475-2840-11-11.
Lipocalin-2 is a novel adipokine with connection to insulin resistance. In this study, we aimed to investigate the association of serum lipocalin-2 with glucose metabolism and other metabolic phenotype in a large-scale Chinese population.
We evaluated serum lipocalin-2 in a cross-sectional sample of 2519 Chinese aged from 50 to 82 year in a Shanghai downtown district by ELISA. Glucose, insulin, lipid profile, inflammatory markers, and adipokines were also measured.
Serum lipocalin-2 was significantly higher in subjects with isolated impaired fasting glucose, isolated impaired glucose tolerance, combined impaired fasting glucose/impaired glucose tolerance and newly-diagnosed type 2 diabetes than in those with normal glucose regulation. Lipocalin-2 elevation was clearly associated with a higher risk for impaired glucose regulation (OR 1.30 for each 10 ng/ml increase in serum lipocalin-2, 95% CI 1.23-1.62, p = 0.009) after adjustment of age, gender, smoking, alcohol drinking, family history of diabetes, serum CRP, serum adiponectin, serum CXCL5, HOMA-IR, BMI, and waist/hip ratio. The OR for participants with impaired glucose regulation and type 2 diabetes was 1.31 (95% CI 1.21-1.69, p < 0.001).
Our findings suggest that elevated serum lipocalin-2 is closely and independently associated with impaired glucose regulation and type 2 diabetes.
脂联素-2 是一种与胰岛素抵抗有关的新型脂肪因子。在这项研究中，我们旨在调查大型中国人群中血清脂联素-2 与葡萄糖代谢和其他代谢表型的关系。
我们通过 ELISA 评估了来自上海市中心区 50 至 82 岁的 2519 名中国成年人的血清脂联素-2。还测量了血糖、胰岛素、血脂谱、炎症标志物和脂肪因子。
与血糖正常调节者相比，单纯空腹血糖受损、单纯糖耐量受损、空腹血糖/糖耐量受损合并以及新诊断的 2 型糖尿病患者的血清脂联素-2 显著升高。脂联素-2 升高与葡萄糖调节受损的风险明显增加相关（血清脂联素-2 每增加 10ng/ml，OR 1.30，95%CI 1.23-1.62，p=0.009），校正年龄、性别、吸烟、饮酒、糖尿病家族史、血清 CRP、血清脂联素、血清 CXCL5、HOMA-IR、BMI 和腰围/臀围比后。葡萄糖调节受损和 2 型糖尿病患者的 OR 为 1.31（95%CI 1.21-1.69，p<0.001）。
我们的研究结果表明，血清脂联素-2 升高与葡萄糖调节受损和 2 型糖尿病密切且独立相关。
