肾素表型：在肾脏中的作用与调节
The renin phenotype: roles and regulation in the kidney.
作者信息
Lopez Maria L S Sequeira, Gomez R Ariel
机构信息
Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA.
出版信息
Curr Opin Nephrol Hypertens. 2010 Jul;19(4):366-71. doi: 10.1097/MNH.0b013e32833aff32.
Abstract
PURPOSE OF REVIEW
Renin cells are fundamental for the control of blood pressure, fluid electrolyte homeostasis and kidney development. This review discusses recent discoveries regarding the mechanisms that control the identity and fate of renin cells and their role in the maintenance of kidney architecture and function.
RECENT FINDINGS
It is now established that cyclic AMP is a crucial factor for the regulation of the renin phenotype. Furthermore, additional factors such as microRNAs and gap junctions have recently emerged as key regulators for the maintenance and proper functioning of renin cells.
SUMMARY
Experiments described in this review will hopefully raise new questions regarding the mechanisms that control the identity, plasticity and function of renin cells.
摘要
综述目的
肾素细胞对于血压控制、体液电解质平衡及肾脏发育至关重要。本综述讨论了关于控制肾素细胞特性和命运的机制及其在维持肾脏结构和功能中作用的最新发现。
最新发现
现已确定环磷酸腺苷是调节肾素表型的关键因素。此外，诸如微小RNA和间隙连接等其他因素最近已成为肾素细胞维持和正常功能的关键调节因子。
总结
本综述中描述的实验有望引发关于控制肾素细胞特性、可塑性和功能机制的新问题。
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