Haot J, Bogomoletz W V, Jouret A, Mainguet P
Service d'Anatomie Pathologique, Cliniques Universitaires Saint-Luc, Bruxelles, Belgium.
Hum Pathol. 1991 Apr;22(4):379-86. doi: 10.1016/0046-8177(91)90086-5.
Ménétrier's disease is a rare form of hypertrophic or hyperplastic gastropathy, characterized by conspicuous thickening of the gastric mucosal folds and foveolar (crypt) hyperplasia. The pathogenesis of Ménétrier's disease remains unresolved. Lymphocytic gastritis is a newly described entity which corresponds endoscopically to varioliform gastritis and is marked by T-lymphocyte infiltration of the surface epithelium and crypts. Five surgical cases and one autopsy case combining the gross and microscopic features of Ménétrier's disease and lymphocytic gastritis are presented. This unusual and hitherto previously undescribed association raises the possibility of a common pathogenesis for Ménétrier's disease and lymphocytic gastritis.
梅内特里耶病是一种罕见的肥厚性或增生性胃病，其特征为胃黏膜皱襞明显增厚和胃小凹（隐窝）增生。梅内特里耶病的发病机制尚未明确。淋巴细胞性胃炎是一种新描述的疾病，在内镜下与痘疮样胃炎相符，其特征为表面上皮和隐窝有T淋巴细胞浸润。本文报告了5例手术病例和1例尸检病例，这些病例兼具梅内特里耶病和淋巴细胞性胃炎的大体及微观特征。这种不寻常且此前未被描述过的关联增加了梅内特里耶病和淋巴细胞性胃炎存在共同发病机制的可能性。
