Miettinen A, Karttunen T J, Alavaikko M
Department of Pathology, University of Oulu, Finland.
Gut. 1995 Oct;37(4):471-6. doi: 10.1136/gut.37.4.471.
Lymphocytic gastritis and primary gastric lymphoma are rare conditions with unknown aetiology. It has recently been suggested that Helicobacter pylori has a role in the pathogenesis of both of them. The occurrence of lymphocytic gastritis and H pylori was studied in a series of patients with primary gastric lymphoma. The cases of primary gastric lymphomas (n = 35) diagnosed in years 1970-1993 were identified. The specimens of 22 cases contained gastric mucosa sufficiently so that the number of intra-epithelial lymphocytes, severity of gastritis, and occurrence of H pylori could be studied. Lymphocytic gastritis was detected in seven of 22 patients (32%), and in most cases both in antral and body mucosa. Atrophy of the body glands was significantly more severe in lymphocytic gastritis patients. H pylori was detected in 13 of all 22 patients (59%); two of seven lymphocytic gastritis patients (29%), and 11 of 15 (73%) of patients without lymphocytic gastritis were H pylori positive. Patients with gastric lymphoma have significantly increased prevalence of lymphocytic gastritis. Rarity of H pylori in these patients might be connected with atrophic changes in body mucosa. Further studies are needed to show the significance of lymphocytic gastritis as a precursor of gastric lymphoma.
淋巴细胞性胃炎和原发性胃淋巴瘤是病因不明的罕见病症。最近有人提出幽门螺杆菌在这两种病症的发病机制中起作用。我们对一系列原发性胃淋巴瘤患者的淋巴细胞性胃炎和幽门螺杆菌的发生情况进行了研究。确定了1970年至1993年间诊断的原发性胃淋巴瘤病例（n = 35）。22例病例的标本含有足够的胃黏膜，因此可以研究上皮内淋巴细胞数量、胃炎严重程度和幽门螺杆菌的发生情况。22例患者中有7例（32%）检测到淋巴细胞性胃炎，大多数病例在胃窦和胃体黏膜均有。淋巴细胞性胃炎患者胃体腺萎缩明显更严重。22例患者中有13例（59%）检测到幽门螺杆菌；7例淋巴细胞性胃炎患者中有2例（29%），15例无淋巴细胞性胃炎患者中有11例（73%）幽门螺杆菌呈阳性。胃淋巴瘤患者淋巴细胞性胃炎的患病率显著增加。这些患者中幽门螺杆菌的罕见可能与胃体黏膜的萎缩性改变有关。需要进一步研究以表明淋巴细胞性胃炎作为胃淋巴瘤前驱病变的意义。
