Rubio C A, Hubbard G
Department of Pathology, Karolinska Institute, Stockholm, Sweden.
In Vivo. 1996 Sep-Oct;10(5):507-10.
While reviewing gastric specimens from 215 baboons, we found diffuse giant mucosal folds in 2 specimens and multiple giant mucosal nodules in another 3. The increased mucosal thickness in those areas was due to giant hyperplasia of the foveolar epithelium. The former 2 specimens were classified as Menetrier's disease (MD) and the latter 3 as Varioliform Lymphocytic Gastritis (VLG), since they were histologically identical to those gastropathies in humans. Whereas MD had diffuse giant hyperplastic foveoli (without lymphocytic infiltration) and prominent glandular cysts, VLG had nodules due to giant hyperplastic foveoli with intraepithelial lymphocytosis. Since the causes leading to gastric MD and VLG in humans remain unknown, the spontaneous occurrence of these two conditions in the baboon may open new avenues for the investigation of possible etiologic factors in the laboratory.
在检查215只狒狒的胃标本时，我们在2个标本中发现了弥漫性巨大黏膜皱襞，在另外3个标本中发现了多个巨大黏膜结节。这些区域黏膜厚度增加是由于小凹上皮的巨大增生。前2个标本被归类为门脉性胃病（MD），后3个标本被归类为痘疮样淋巴细胞性胃炎（VLG），因为它们在组织学上与人类的这些胃病相同。MD有弥漫性巨大增生性小凹（无淋巴细胞浸润）和明显的腺囊肿，而VLG有因巨大增生性小凹伴上皮内淋巴细胞增多形成的结节。由于人类胃MD和VLG的病因尚不清楚，这两种情况在狒狒中的自发出现可能为在实验室研究可能的病因因素开辟新途径。
