Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Diabetes Care. 2010 Aug;33(8):1840-4. doi: 10.2337/dc09-1073. Epub 2010 May 26.
Plasma protein growth arrest-specific 6 (Gas6) is important to the inflammatory process and is involved in the development of diabetic renal and vascular complications. We set out to determine whether plasma Gas6 levels are associated with altered glucose tolerance, insulin sensitivity, inflammation, and endothelial dysfunction.
A total of 278 adults, including 96 with normal glucose tolerance (NGT), 82 with impaired glucose tolerance (IGT), and 100 with type 2 diabetes were recruited. Plasma Gas6 concentration and biochemical, proinflammatory, and endothelial variables were determined. Insulin sensitivity was examined by homeostasis model assessment.
Plasma Gas6 concentration was significantly lower among patients with type 2 diabetes compared with subjects with NGT (P < 0.001). The plasma Gas6 value was inversely correlated with fasting glucose, tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and vascular cell adhesion molecule (VCAM)-1. In multivariate logistic regression analysis, after adjustment for established diabetes risk factors, higher plasma Gas6 concentrations were significantly associated with a decreased risk of type 2 diabetes. Moreover, the association became slightly stronger after further adjustment for TNF-alpha, IL-6, high-sensitive C-reactive protein, E-selectin, intercellular adhesion molecule-1, and VCAM-1.
Plasma Gas6 is associated with altered glucose tolerance, inflammation, and endothelial dysfunction. It also may represent a novel independent risk factor of type 2 diabetes and a potential surrogate marker of inflammation and endothelial dysfunction.
血浆蛋白生长停滞特异性 6（Gas6）对于炎症过程很重要，并且参与了糖尿病肾脏和血管并发症的发展。我们旨在确定血浆 Gas6 水平是否与葡萄糖耐量改变、胰岛素敏感性、炎症和内皮功能障碍有关。
共招募了 278 名成年人，包括 96 名血糖正常者（NGT）、82 名糖耐量受损者（IGT）和 100 名 2 型糖尿病患者。测定了血浆 Gas6 浓度和生化、促炎和内皮变量。通过稳态模型评估检查胰岛素敏感性。
与 NGT 受试者相比，2 型糖尿病患者的血浆 Gas6 浓度明显降低（P<0.001）。血浆 Gas6 值与空腹血糖、肿瘤坏死因子（TNF）-α、白细胞介素（IL）-6 和血管细胞黏附分子（VCAM）-1 呈负相关。在多元逻辑回归分析中，在校正了既定的糖尿病危险因素后，较高的血浆 Gas6 浓度与 2 型糖尿病的风险降低显著相关。此外，在进一步调整 TNF-α、IL-6、高敏 C 反应蛋白、E-选择素、细胞间黏附分子-1 和 VCAM-1 后，这种相关性变得更强。
血浆 Gas6 与葡萄糖耐量改变、炎症和内皮功能障碍有关。它也可能代表 2 型糖尿病的一个新的独立危险因素，以及炎症和内皮功能障碍的潜在替代标志物。
