Fontana Vanina Andrea, Sanchez Melisa, Cebral Elisa, Calvo Juan Carlos
Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina.
Biocell. 2010 Apr;34(1):37-43.
Implantation is one of the most regulated processes in human reproduction, by endocrine and immunological systems. Cytokines are involved in embryo-maternal communication and an impaired balance could result in pregnancy loss. Here we investigated the effect of interleukin 1-beta on the activity of two important metalloproteinases (MMP-2 and MMP-9) that are involved in extracellular matrix remodeling as well as the secretion of leptin, one of the reproductive hormones actively regulating their activity and secretion. We found that IL-1 beta activates matrix metalloproteinase activity as well as increases leptin secretion. We propose that this interleukin, through the regulation of leptin, in turn activates matrix metalloproteinases which results in an increased cytotrophoblast invasion.
着床是人类生殖过程中受内分泌和免疫系统调控最为严格的过程之一。细胞因子参与胚胎与母体间的交流，而平衡受损可能导致妊娠丢失。在此，我们研究了白细胞介素1-β对两种重要金属蛋白酶（MMP-2和MMP-9）活性的影响，这两种酶参与细胞外基质重塑，同时还研究了其对瘦素分泌的影响，瘦素是一种积极调节它们活性和分泌的生殖激素。我们发现白细胞介素1-β可激活基质金属蛋白酶活性并增加瘦素分泌。我们提出，这种白细胞介素通过对瘦素的调节，继而激活基质金属蛋白酶，从而导致细胞滋养层侵袭增加。
