Clinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China.
Front Immunol. 2019 Apr 15;10:792. doi: 10.3389/fimmu.2019.00792. eCollection 2019.
The immunology of pregnancy is complex and poorly defined. During the complex process of pregnancy, macrophages secrete many cytokines/chemokines and play pivotal roles in the maintenance of maternal-fetal tolerance. Here, we summarized the current knowledge of macrophage polarization and the mechanisms involved in physiological or pathological pregnancy processes, including miscarriage, preeclampsia, and preterm birth. Although current evidence provides a compelling argument that macrophages are important in pregnancy, our understanding of the roles and mechanisms of macrophages in pregnancy is still rudimentary. Since macrophages exhibit functional plasticity, they may be ideal targets for therapeutic manipulation during pathological pregnancy. Additional studies are needed to better define the functions and mechanisms of various macrophage subsets in both normal and pathological pregnancy.
妊娠的免疫学非常复杂，目前仍未完全明确。在妊娠这一复杂过程中，巨噬细胞会分泌多种细胞因子/趋化因子，并在维持母胎耐受中发挥关键作用。在这里，我们总结了目前关于巨噬细胞极化及其在生理或病理妊娠过程（包括流产、子痫前期和早产）中相关机制的知识。尽管目前的证据有力地证明了巨噬细胞在妊娠中具有重要作用，但我们对巨噬细胞在妊娠中的作用和机制的理解仍处于起步阶段。由于巨噬细胞表现出功能可塑性，因此它们可能是病理性妊娠治疗干预的理想靶点。需要进一步的研究来更好地定义正常和病理性妊娠中各种巨噬细胞亚群的功能和机制。
